A major limitation of organ allotransplantation is the insufficient supply of donor organs.
Consequently, thousands of patients die every year while waiting for a transplant. Progress …

Organ allotransplantation has now reached an impassable ceiling inherent to the limited
supply of human donor organs. In the United States, there are currently over 100,000 …

Preventing xenograft rejection is one of the greatest challenges of transplantation medicine.
Here, we describe a reproducible, long-term survival of cardiac xenografts from alpha 1-3 …

Xenotransplantation research has made considerable progress in recent years, largely
through the increasing availability of pigs with multiple genetic modifications. We suggest …

There is a critical shortage in the number of deceased human organs that become available
for the purposes of clinical transplantation. This problem might be resolved by the …

For many patients with terminal/advanced cardiac failure, heart transplantation is the most
effective, durable treatment option, and offers the best prospects for a high quality of life. The …

The immunologic barriers to successful xenotransplantation are related to the presence of
natural anti‐pig antibodies in humans and non‐human primates that bind to antigens …

Abstract Analysis of non‐Gal antibody induced after pig‐to‐baboon cardiac
xenotransplantation identified the glycan produced by porcine beta‐1, 4‐N‐acetyl …

Background Xenograft rejection of pigs organs with an engineered mutation in the GGTA‐1
gene (GTKO) remains a predominantly antibody mediated process which is directed to a …

The discrepancy between organ need and organ availability represents one of the major
limitations in the field of transplantation. One possible solution to this problem is …