Channeling Nicotinamide Phosphoribosyltransferase (NAMPT) to Address Life and Death
Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the rate-limiting step in NAD+
biosynthesis via salvage of NAM formed from catabolism of NAD+ by proteins with NADase …
biosynthesis via salvage of NAM formed from catabolism of NAD+ by proteins with NADase …
ADP-ribosylation: an emerging direction for disease treatment
YT Liu, Y Che, HL Qiu, HX Xia, YZ Feng… - Ageing Research …, 2023 - Elsevier
ADP-ribosylation (ADPr) is a dynamically reversible post-translational modification (PTM)
driven primarily by ADP-ribosyltransferases (ADPRTs or ARTs), which have ADP-ribosyl …
driven primarily by ADP-ribosyltransferases (ADPRTs or ARTs), which have ADP-ribosyl …
Layered mechanisms regulating the human mitochondrial NAD+ transporter SLC25A51
S Goyal, XA Cambronne - Biochemical Society Transactions, 2023 - portlandpress.com
SLC25A51 is the primary mitochondrial NAD+ transporter in humans and controls many
local reactions by mediating the influx of oxidized NAD+. Intriguingly, SLC25A51 lacks …
local reactions by mediating the influx of oxidized NAD+. Intriguingly, SLC25A51 lacks …
NAD metabolism-related genes provide prognostic value and potential therapeutic insights for acute myeloid leukemia
Y Cao, W Shu, P Jin, J Li, H Zhu, X Chen… - Frontiers in …, 2024 - frontiersin.org
Introduction Acute myeloid leukemia (AML) is an aggressive blood cancer with high
heterogeneity and poor prognosis. Although the metabolic reprogramming of nicotinamide …
heterogeneity and poor prognosis. Although the metabolic reprogramming of nicotinamide …
NMNATs expression inhibition mediated NAD+ deficiency plays a critical role in doxorubicin-induced hepatotoxicity in mice
F Cheng, Y Zhang, H Xiong, M Zhao, Q Wang… - Toxicology and Applied …, 2024 - Elsevier
Doxorubicin (DOX) is one of the most widely used antineoplastic drugs with known
cardiotoxicity while other organ toxicity, such as hepatotoxicity is not well defined. This study …
cardiotoxicity while other organ toxicity, such as hepatotoxicity is not well defined. This study …
β-烟酰胺单核苷酸及其在维持基因组稳态中的研究进展.
魏明臣， 牛梦伟， 宋英杰， 韩尧… - Journal of Modern …, 2024 - search.ebscohost.com
β-烟酰胺单核苷酸(NMN) 是辅酶Ⅰ 烟酰胺腺嘌呤二核苷酸(NAD+) 的前体, 其主要通过NAD+
在细胞生命过程中发挥关键作用, 包括DNA 损伤修复信号通路, 氧化还原反应和代谢反应等 …
在细胞生命过程中发挥关键作用, 包括DNA 损伤修复信号通路, 氧化还原反应和代谢反应等 …
Development of Chemogenetic Biosensors with Large Dynamic Ranges and Spectral Flexibility
L Hellweg - 2024 - archiv.ub.uni-heidelberg.de
Understanding cellular processes at the molecular level is fundamental for gaining insights
into biological mechanisms and their implications in health and disease. Fluorescent …
into biological mechanisms and their implications in health and disease. Fluorescent …