Tryptophan is an essential amino acid from dietary proteins. It can be metabolized into
different metabolites in both the gut microbiota and tissue cells. Tryptophan metabolites such …

The increasing prevalence of diabetes and its complications, such as cardiovascular and
kidney disease, remains a huge burden globally. Identification of biomarkers for the …

Gut microbiota alterations might affect the development of Alzheimer's disease (AD) through
microbiota-derived metabolites. For example, microbiota-derived Indoles via tryptophan …

The interaction between host and microorganism widely affects the immune and metabolic
status. Indole and its derivatives are metabolites produced by the metabolism of tryptophan …

The tryptophan–kynurenine pathway (Trp–KYN) is the major route for tryptophan conversion
in the brain and in the periphery. Kynurenines display a wide range of biological actions …

Abstract Type 2 diabetes (T2D) is a metabolic disease characterized by hyperglycemia.
Intake of dietary fiber is inversely associated with risks of T2D. Here, metabolomics and 16S …

Gut microbiota dysbiosis is associated with the development of rheumatoid arthritis (RA).
Sinomenine (SIN) is an effective immunosuppressive and anti-inflammatory drug used for …

The increasing prevalence of metabolic syndrome has become a serious public health
problem. Certain bacteria-derived metabolites play a key role in maintaining human health …

The gut is colonized by many commensal microorganisms, and the diversity and metabolic
patterns of microorganisms profoundly influence the intestinal health. These microbial …

Although previous studies suggest that amino acids (AAs) and microbiota-related
metabolites (MRMs) are associated with type 2 diabetes mellitus (T2DM), the results remain …