It has long been axiomatic that a protein's structure determines its function. Intrinsically
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …

Substantial evidence links α-synuclein, a small highly conserved presynaptic protein with
unknown function, to both familial and sporadic Parkinson's disease (PD). α-Synuclein has …

Copper (Cu) is an essential micronutrient required for the activity of redox‐active enzymes
involved in critical metabolic reactions, signaling pathways, and biological functions …

The basic role of metal ions including copper, zinc and iron in neurological pathologies is
generally accepted. The relationship between the development of disease and particular …

Copper (Cu) is essential for living organisms, and acts as a cofactor in many metabolic
enzymes. To avoid the toxicity of free Cu, organisms have specific transport systems that …

There are a group of diseases associated with protein misfolding and accumulation into
amyloid fibers. Many of these diseases have a major impact on human health, in particular …

The involvement of copper in numerous physiological processes makes this metal ion
essential for human life. Alterations in copper homeostasis might have deleterious …

Several diseases share misfolding of different peptides and proteins as a key feature for
their development. This is the case of important neurodegenerative diseases such as …

Parkinson's disease (PD) comprises a spectrum of disorders with differing subtypes, the vast
majority of which share Lewy bodies (LB) as a characteristic pathological hallmark. The …

Cellular oxidative stress serves as a common denominator in many neurodegenerative
disorders, including Parkinson's disease. Here we use in-cell NMR spectroscopy to study …