Replication of the coronavirus genome requires continuous RNA synthesis, whereas
transcription is a discontinuous process unique among RNA viruses. Transcription includes …

Preliminary studies indicate that a robust immune response across different cell types is
crucial in recovery from coronavirus disease 2019 (COVID-19). An enormous number of …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)—a new coronavirus that
has led to a worldwide pandemic—has a furin cleavage site (PRRAR) in its spike protein …

The SARS-CoV-2 pandemic has caused extreme human suffering and economic harm. We
generated and characterized a new mouse-adapted SARS-CoV-2 virus that captures …

The etiologic agent of an outbreak of pneumonia in Wuhan, China, was identified as severe
acute respiratory syndrome coronavirus 2 in January 2020. A patient in the United States …

Coronaviruses are adept at evading host antiviral pathways induced by viral double-
stranded RNA, including interferon (IFN) signaling, oligoadenylate synthetase–ribonuclease …

ABSTRACT SARS-CoV-2, a novel coronavirus (CoV) that causes COVID-19, has recently
emerged causing an ongoing outbreak of viral pneumonia around the world. While distinct …

Emerging coronaviruses (CoVs) cause severe disease in humans, but no approved
therapeutics are available. The CoV nsp14 exoribonuclease (ExoN) has complicated …

Emerging viral infections are difficult to control because heterogeneous members
periodically cycle in and out of humans and zoonotic hosts, complicating the development of …

To date, limited genetic changes in the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) genome have been described. Here, we report a 382-nucleotide (nt) deletion …