LncRNA-mediated regulation of cell signaling in cancer
To date, a large number of long non-coding RNAs (lncRNAs) have been recently discovered
through functional genomics studies. Importantly, lncRNAs have been shown, in many …
through functional genomics studies. Importantly, lncRNAs have been shown, in many …
Nuclear long noncoding RNAs: key regulators of gene expression
A significant portion of the human genome encodes genes that transcribe long nonprotein-
coding RNAs (lncRNAs). A large number of lncRNAs localize in the nucleus, either enriched …
coding RNAs (lncRNAs). A large number of lncRNAs localize in the nucleus, either enriched …
Unique features of long non-coding RNA biogenesis and function
Long non-coding RNAs (lncRNAs) are a diverse class of RNAs that engage in numerous
biological processes across every branch of life. Although initially discovered as mRNA-like …
biological processes across every branch of life. Although initially discovered as mRNA-like …
A 360 view of circular RNAs: From biogenesis to functions
JE Wilusz - Wiley Interdisciplinary Reviews: RNA, 2018 - Wiley Online Library
The first circular RNA (circRNA) was identified more than 40 years ago, but it was only
recently appreciated that circRNAs are common outputs of many eukaryotic protein‐coding …
recently appreciated that circRNAs are common outputs of many eukaryotic protein‐coding …
The long noncoding RNA Malat1: Its physiological and pathophysiological functions
Recent studies suggest that in humans, DNA sequences responsible for protein coding
regions comprise only 2% of the total genome. The rest of the transcripts result in RNA …
regions comprise only 2% of the total genome. The rest of the transcripts result in RNA …
Non-coding RNAs in cardiovascular diseases: diagnostic and therapeutic perspectives
Recent research has demonstrated that the non-coding genome plays a key role in genetic
programming and gene regulation during development as well as in health and …
programming and gene regulation during development as well as in health and …
MALAT1: a druggable long non-coding RNA for targeted anti-cancer approaches
The deeper understanding of non-coding RNAs has recently changed the dogma of
molecular biology assuming protein-coding genes as unique functional biological effectors …
molecular biology assuming protein-coding genes as unique functional biological effectors …
The regulation and functions of the nuclear RNA exosome complex
The RNA exosome complex is the most versatile RNA-degradation machine in eukaryotes.
The exosome has a central role in several aspects of RNA biogenesis, including RNA …
The exosome has a central role in several aspects of RNA biogenesis, including RNA …
[HTML][HTML] Emerging roles of lncRNAs in the post-transcriptional regulation in cancer
RZ He, DX Luo, YY Mo - Genes & diseases, 2019 - Elsevier
Accumulating evidence indicates that long non-coding RNAs (lncRNAs) can play a pivotal
role in regulation of diverse cellular processes. In particular, lncRNAs can serve as master …
role in regulation of diverse cellular processes. In particular, lncRNAs can serve as master …
Evaluation of two main RNA-seq approaches for gene quantification in clinical RNA sequencing: polyA+ selection versus rRNA depletion
To allow efficient transcript/gene detection, highly abundant ribosomal RNAs (rRNA) are
generally removed from total RNA either by positive polyA+ selection or by rRNA depletion …
generally removed from total RNA either by positive polyA+ selection or by rRNA depletion …