Synapses are essential components of neurons and allow information to travel coordinately
throughout the nervous system to adjust behavior to environmental stimuli and to control …

Channelopathies are a heterogeneous group of disorders resulting from the dysfunction of
ion channels located in the membranes of all cells and many cellular organelles. These …

Glycine transporters are endogenous regulators of the dual functions of glycine, which acts
as a classical inhibitory neurotransmitter at glycinergic synapses and as a modulator of …

Strychnine-sensitive glycine receptors (GlyRs) mediate synaptic inhibition in the spinal cord,
brainstem, and other regions of the mammalian central nervous system. In this minireview …

The potassium-chloride co-transporter KCC2, encoded by SLC12A5, plays a fundamental
role in fast synaptic inhibition by maintaining a hyperpolarizing gradient for chloride ions …

Antifibrinolytic drugs are widely used to reduce blood loss during surgery. One serious
adverse effect of these drugs is convulsive seizures; however, the mechanisms underlying …

Understanding the genetic variation in GABA A receptor subunit genes (GABRs), GABRA1-
6, GABRB1-3, GABRG1-3 and GABRD, in individuals affected by epilepsy may improve the …

Hyperekplexia is a rare neurological disorder characterized by neonatal hypertonia,
exaggerated startle responses to unexpected stimuli and a variable incidence of apnoea …

Currently, there are two types of drugs on the market: orthosteric, which bind at the active
site; and allosteric, which bind elsewhere on the protein surface, and allosterically change …

Since the discovery of the major excitatory and inhibitory neurotransmitters and their
receptors in the brain, many have deliberated over their likely structures and how these may …