Heme oxygenases (HO) catabolize free heme, that is, iron (Fe) protoporphyrin (IX), into
equimolar amounts of Fe2+, carbon monoxide (CO), and biliverdin. The stress-responsive …

Angiogenesis involves the formation of new blood vessels and is critical for fundamental
events such as development and repair after injury. Perturbances in angiogenesis contribute …

Background—Preeclampsia is characterized clinically by hypertension and proteinuria.
Soluble Flt-1 (sFlt-1; also known as soluble vascular endothelial growth factor receptor-1 …

Heme oxygenase-1, an enzyme degrading heme to carbon monoxide, iron, and biliverdin,
has been recognized as playing a crucial role in cellular defense against stressful …

Pre-eclampsia is a serious hypertensive condition of pregnancy associated with high
maternal and fetal morbidity and mortality. Se intake or status has been linked to the …

Background Preterm birth occurs in 5%–13% of pregnancies. It is a leading cause of
perinatal mortality and morbidity and has adverse long-term consequences for the health of …

Heme oxygenase (HO) is the rate-limiting enzyme in the heme catabolic pathway and highly
expressed in the placenta. Deficiencies in HO-1, the inducible isoform, have been …

Inflammatory bowel disease (IBD) is a gastrointestinal disease that involves chronic mucosal
or submucosal lesions that affect tissue integrity. Although IBD is not life-threatening, it …

Preeclampsia, characterized by new-onset gestational hypertension and proteinuria, is a
common and serious complication of pregnancy. Evidence from both animal and human …

Several recently published studies have suggested that decreasing VEGF levels result in
placental oxidative stress in preeclampsia, although the question as to how decreased …