Despite having been identified as the organism that causes tuberculosis in 1882,
Mycobacterium tuberculosis has managed to still evade our understanding of the protective …

Tuberculosis (TB) is a serious global public health challenge that results in significant
morbidity and mortality worldwide. TB is caused by infection with the bacilli Mycobacterium …

Infection with Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), results
in a range of clinical presentations in humans. Most infections manifest as a clinically …

The functional role of CD8+ lymphocytes in tuberculosis remains poorly understood. We
depleted innate and/or adaptive CD8+ lymphocytes in macaques and showed that loss of all …

Mycobacterium tuberculosis lung infection results in a complex multicellular structure: the
granuloma. In some granulomas, immune activity promotes bacterial clearance, but in …

Over 30% of the world's population is infected with Mycobacterium tuberculosis (Mtb), yet
only∼ 5–10% will develop clinical disease. Despite considerable effort, researchers …

Immunological tests provide evidence of latent tuberculosis in one third of the global
population, which corresponds to more than two billion individuals. Latent tuberculosis is …

Mycobacterium tuberculosis complex (MTBC) refers to a group of mycobacteria
encompassing nine members of closely related species that causes tuberculosis in animals …

Tuberculosis (TB) lesions are extremely complex and dynamic. Here, we review the multiple
types and fates of pulmonary lesions that form following infection by M ycobacterium …

Immune responses to pathogens are complex and not well understood in many diseases,
and this is especially true for infections by persistent pathogens. One mechanism that allows …