Microwave encounters ionic liquid: synergistic mechanism, synthesis and emerging applications

Z Zhao, H Li, X Gao - Chemical Reviews, 2023 - ACS Publications
Progress in microwave (MW) energy application technology has stimulated remarkable
advances in manufacturing and high-quality applications of ionic liquids (ILs) that are …

Discovery of new cholesteryl ester transfer protein inhibitors via ligand-based pharmacophore modeling and QSAR analysis followed by synthetic exploration

RA Khalaf, GA Sheikha, Y Bustanji, MO Taha - European journal of …, 2010 - Elsevier
Cholesteryl ester transfer protein (CETP) is involved in trafficking lipoprotein particles and
neutral lipids between HDL and LDL and therefore is considered a valid target for treating …

High Target Homology Does Not Guarantee Inhibition: Aminothiazoles Emerge as Inhibitors of Plasmodium falciparum

S Johannsen, RM Gierse, A Krüger… - ACS Infectious …, 2024 - ACS Publications
In this study, we identified three novel compound classes with potent activity against
Plasmodium falciparum, the most dangerous human malarial parasite. Resistance of this …

Application of silica gel-supported polyphosphoric acid (PPA/SiO2) as a reusable solid acid catalyst to the synthesis of 3-benzoylisoxazoles and isoxazolines

K Itoh, T Aoyama, H Satoh, Y Fujii, H Sakamaki… - Tetrahedron letters, 2011 - Elsevier
Application of silica gel-supported polyphosphoric acid (PPA/SiO2) as a reusable solid acid
catalyst to the synthesis of 3-benzoylisoxazoles and isoxazolines - ScienceDirect Skip to …

[HTML][HTML] Design, synthesis, and biological evaluation of benzylamino-methanone based cholesteryl ester transfer protein inhibitors

GA Sheikha, R Abu Khalaf, A Melhem, G Albadawi - Molecules, 2010 - mdpi.com
Cholesteryl ester transfer protein (CETP) is a glycoprotein involved in transporting
lipoprotein particles and neutral lipids between high-density lipoprotein (HDL) and low …

An expedient route to heterocycles through α-arylation of ketones and arylamides by microwave induced thermal S RN 1 reactions

SM Soria-Castro, DA Caminos, AB Penenory - RSC Advances, 2014 - pubs.rsc.org
Microwave irradiation promotes a quick aromatic nucleophilic substitution by a thermally
induced electron transfer process to form new C–C bonds by the coupling of aryl radicals …

Selective Metal-Free Deoxygenation of Unsymmetrical 1, 2-Dicarbonyl Compounds by Chlorotrimethylsilane and Sodium Iodide

LZ Yuan, D Renko, I Khelifi, O Provot, JD Brion… - Organic …, 2016 - ACS Publications
For the first time, the combination of chlorotrimethylsilane with NaI is used as a selective
reducting system toward 1, 2-diketones. This combination is successfully evaluated with …

Chemoselective generation of acyl phosphates, acylium ion equivalents, from carboxylic acids and an organophosphate ester in the presence of a Brønsted acid

A Sumita, Y Otani, T Ohwada - Chemical Communications, 2017 - pubs.rsc.org
We describe the chemoselective conversion of carboxylic acids to functional aromatic
ketones promoted by a tailored organophosphate ester in the presence of a Brønsted acid …

Dearomative C–C and C–N bond cleavage of 2-arylindoles: transition-metal-free access to 2-aminoarylphenones

S Luo, Z Hu, Q Zhu - Organic Chemistry Frontiers, 2016 - pubs.rsc.org
A transition-metal-free conversion of 2-arylindoles to 2-aminoarylphenones, using
environmentally benign O2 as the sole oxidant, has been developed. This novel oxidative …

Silica-supported polyphosphoric acid in the synthesis of 4-substituted tetrahydroisoquinoline derivatives

S Manolov, S Nikolova, I Ivanov - Molecules, 2013 - mdpi.com
We report herein an application of an α-amidoalkylation reaction, as an alternative efficient
synthesis of 4-aryl-and 4-methyl-1, 2, 3, 4-tetrahydroisoquinoline derivatives. The amides …