Proliferative vitreoretinopathy: a new concept of disease pathogenesis and practical consequences

JC Pastor, J Rojas, S Pastor-Idoate, S Di Lauro… - Progress in retinal and …, 2016 - Elsevier
During the last four decades, proliferative vitreoretinopathy (PVR) has defied the efforts of
many researchers to prevent its occurrence or development. Thus, PVR is still the major …

[HTML][HTML] Old and new applications of non-anticoagulant heparin

G Cassinelli, A Naggi - International Journal of Cardiology, 2016 - Elsevier
The aim of this chapter is to provide an overview of non-anticoagulant effects of heparins
and their potential use in new therapeutic applications. Heparin and heparin derivatives …

Fundamentals, challenges, and nanomedicine‐based solutions for ocular diseases

DA Srinivasarao, G Lohiya… - Wiley Interdisciplinary …, 2019 - Wiley Online Library
The eye consists of sensitive, compactly adjoined tissue structures which act as strong
physical (static) and physiological (dynamic) barriers that prevent entry of foreign bodies into …

[HTML][HTML] Topical delivery of a small molecule RUNX1 transcription factor inhibitor for the treatment of proliferative vitreoretinopathy

S Delgado-Tirado, D Amarnani, G Zhao, EJ Rossin… - Scientific reports, 2020 - nature.com
Proliferative vitreoretinopathy (PVR) is the leading cause of retinal detachment surgery
failure. Despite significant advances in vitreoretinal surgery, it still remains without an …

[HTML][HTML] Molecular pathogenesis of rhegmatogenous retinal detachment

T Öhman, L Gawriyski, S Miettinen, M Varjosalo… - Scientific reports, 2021 - nature.com
Rhegmatogenous retinal detachment (RRD) is an ophthalmic emergency, which usually
requires prompt surgery to prevent further detachment and restore sensory function …

Intravitreal methotrexate for the treatment of proliferative vitreoretinopathy

JD Benner, D Dao, JW Butler… - BMJ Open …, 2019 - bmjophth.bmj.com
Background/aims Preventing and treating proliferative vitreoretinopathy (PVR) remain a
serious challenge for vitreoretinal surgeons. PVR is a devastating complication of retinal …

E-cadherin to N-cadherin switching in the TGF-β1 mediated retinal pigment epithelial to mesenchymal transition

J Wei, L Wu, S Yang, C Zhang, L Feng, M Wang… - Experimental Eye …, 2022 - Elsevier
A serious form of ocular fibrotic disease is proliferative vitreoretinopathy (PVR) that can
ultimately lead to blindness. While the pathogenesis of PVR is known to be closely tied to …

Recent updates on ocular disease management with ophthalmic ointments

AC Bisen, A Dubey, S Agrawal, A Biswas… - Therapeutic …, 2024 - Taylor & Francis
Ophthalmic diseases can result in permanent vision loss and blindness. Convenient topical
and systemic treatments are preferred to address these sight-threatening conditions …

[HTML][HTML] Effect of methotrexate on an in vitro patient-derived model of proliferative vitreoretinopathy

D Amarnani, AI Machuca-Parra… - … & Visual Science, 2017 - iovs.arvojournals.org
Purpose: The purpose of this study was to develop a method for isolating, culturing, and
characterizing cells from patient-derived membranes in proliferative vitreoretinopathy (PVR) …

[HTML][HTML] Polarity and epithelial-mesenchymal transition of retinal pigment epithelial cells in proliferative vitreoretinopathy

H Zou, C Shan, L Ma, J Liu, N Yang, J Zhao - PeerJ, 2020 - peerj.com
Under physiological conditions, retinal pigment epithelium (RPE) is a cellular monolayer
composed of mitotically quiescent cells. Tight junctions and adherens junctions maintain the …