Animal models of Duchenne muscular dystrophy: from basic mechanisms to gene therapy

JW McGreevy, CH Hakim… - Disease models & …, 2015 - journals.biologists.com
Duchenne muscular dystrophy (DMD) is a progressive muscle-wasting disorder. It is caused
by loss-of-function mutations in the dystrophin gene. Currently, there is no cure. A highly …

Current translational research and murine models for Duchenne muscular dystrophy

M Rodrigues, Y Echigoya, S Fukada… - Journal of …, 2016 - content.iospress.com
Duchenne muscular dystrophy (DMD) is an X-linked genetic disorder characterized by
progressive muscle degeneration. Mutations in the DMD gene result in the absence of …

[图书][B] Applied animal endocrinology

EJ Squires - 2024 - cabidigitallibrary.org
This book explains the role of hormones in improving and monitoring the production,
performance, reproduction, behaviour and health of livestock animals, focusing on cattle …

[图书][B] Anesthesia and analgesia in laboratory animals

M Dyson, P Jirkof, J Lofgren, E Nunamaker, D Pang - 2023 - books.google.com
Anesthesia and Analgesia in Laboratory Animals focuses on the special anesthetic,
analgesic and postoperative care requirements associated with experimental interventions …

[HTML][HTML] Brain Dp140 alters glutamatergic transmission and social behaviour in the mdx52 mouse model of Duchenne muscular dystrophy

Y Hashimoto, H Kuniishi, K Sakai, Y Fukushima… - Progress in …, 2022 - Elsevier
Duchenne muscular dystrophy (DMD) is a muscle disorder caused by DMD mutations and is
characterized by neurobehavioural comorbidities due to dystrophin deficiency in the brain …

Relationships linking emotional, motor, cognitive and GABAergic dysfunctions in dystrophin-deficient mdx mice

C Vaillend, R Chaussenot - Human molecular genetics, 2017 - academic.oup.com
Alterations in the Duchenne muscular dystrophy (DMD) gene have been associated with
enhanced stress reactivity in vertebrate species, suggesting a role for brain dystrophin in …

Emotional behavior and brain anatomy of the mdx52 mouse model of Duchenne muscular dystrophy

A Saoudi, F Zarrouki, C Sebrié… - Disease models & …, 2021 - journals.biologists.com
ABSTRACT The exon-52-deleted mdx52 mouse is a critical model of Duchenne muscular
dystrophy (DMD), as it features a deletion in a hotspot region of the DMD gene, frequently …

Biology and diseases of swine

KL Helke, PC Ezell, R Duran-Struuck… - Laboratory Animal …, 2015 - Elsevier
Swine are used in biomedical research as models for biomedical research and for teaching.
This chapter covers normative biology and behavior along with common and emerging …

Nervous and locomotor system

DM Madson, PHE Arruda, BL Arruda - Diseases of swine, 2019 - Wiley Online Library
Disorders, diseases, and deficits related to mentation and locomotion are both production
and welfare concerns. Nervous disorders commonly occur with sudden onset or acute …

Pharmacologic management of Duchenne muscular dystrophy: target identification and preclinical trials

JN Kornegay, CF Spurney, PP Nghiem… - ILAR …, 2014 - academic.oup.com
Duchenne muscular dystrophy (DMD) is an X-linked human disorder in which absence of
the protein dystrophin causes degeneration of skeletal and cardiac muscle. For the sake of …