The alphaviruses are a genus of 26 enveloped viruses that cause disease in humans and
domestic animals. Mosquitoes or other hematophagous arthropods serve as vectors for …

▪ Abstract Significant progress has been made in elucidating the mechanisms of viral
membrane fusion proteins; both those that function at low, as well as those that function at …

Dengue virus enters a host cell when the viral envelope glycoprotein, E, binds to a receptor
and responds by conformational rearrangement to the reduced pH of an endosome. The …

The envelope protein E of the flavivirus tick-borne encephalitis (TBE) virus promotes cell
entry by inducing fusion of the viral membrane with an intracellular membrane after uptake …

Common themes are emerging from the study of viral, cell-cell, intracellular, and liposome
fusion. Viral and cellular membrane fusion events are mediated by fusion proteins or fusion …

Enveloped viruses encode specialized fusion proteins which promote the merger of viral
and cell membranes, permitting the cytosolic release of the viral cores. Understanding the …

The study of enveloped animal viruses has greatly advanced our understanding of the
general properties of membrane fusion and of the specific pathways that viruses use to infect …

Semliki Forest virus serves as a paradigm for membrane fusion and assembly. Our
icosahedral reconstruction combined 5276 particle images from 48 cryo-electron …

The structure of the lipid-enveloped Sindbis virus has been determined by fitting atomic
resolution crystallographic structures of component proteins into an 11-Å resolution …

Alphavirus dogma has long dictated the production of a discrete set of structural proteins
during infection of a cell: capsid, pE2, 6K, and E1. However, bioinformatic analyses of …