Biomedical research is undergoing a paradigm shift towards approaches centred on human
disease models owing to the notoriously high failure rates of the current drug development …

The surfaces of human internal organs are lined by a mucus layer that ensures symbiotic
relationships with commensal microbiome while protecting against potentially injurious …

The cervix is the gateway to the upper female reproductive tract, connecting the uterus and
vagina. It plays crucial roles in fertility and pregnancy maintenance from onset until delivery …

Chlamydia trachomatis and human papillomavirus (HPV) are the most common pathogens
found in sexually transmitted infections (STIs), and both are known to increase the risk of …

Highlights•Chlamydia infections have damaging consequences on female reproductive
health.•Diverse model systems are required to understand Chlamydia-host …

The recent spike in the instances of complex physiological host-microbe interactions has
raised the demand for developing in vitro models that recapitulate the microbial …

In adapting to the intracellular niche, obligate intracellular bacteria usually undergo a
reduction of genome size by eliminating genes not needed for intracellular survival. These …

The global incidence of sexually transmitted infections (STIs) remains high, with the World
Health Organization (WHO) estimating that over 1 million people acquire STIs daily. STIs …

Chlamydia trachomatis and human papilloma virus (HPV) are the two most common
sexually transmitted infections among women. HPV infection can increase the risk of cervical …

Recent development of human three-dimensional organoid cultures has opened new doors
and opportunities ranging from modelling human development in vitro to personalised …