Cancer cell heterogeneity & plasticity in glioblastoma and brain tumors

A Lauko, A Lo, MS Ahluwalia, JD Lathia - Seminars in cancer biology, 2022 - Elsevier
Brain tumors remain one of the most difficult tumors to treat and, depending on the
diagnosis, have a poor prognosis. Of brain tumors, glioblastoma (GBM) is the most common …

Tumor microenvironment in glioma invasion

S Tamai, T Ichinose, T Tsutsui, S Tanaka, F Garaeva… - Brain Sciences, 2022 - mdpi.com
A major malignant trait of gliomas is their remarkable infiltration capacity. When glioma
develops, the tumor cells have already reached the distant part. Therefore, complete …

Single-cell RNA sequencing reveals immunosuppressive myeloid cell diversity during malignant progression in a murine model of glioma

S Rajendran, Y Hu, A Canella, C Peterson, A Gross… - Cell reports, 2023 - cell.com
Recent studies have shown the importance of the dynamic tumor microenvironment (TME) in
high-grade gliomas (HGGs). In particular, myeloid cells are known to mediate …

Temozolomide-induced hypermutation is associated with distant recurrence and reduced survival after high-grade transformation of low-grade IDH-mutant gliomas

Y Yu, J Villanueva-Meyer, MR Grimmer, S Hilz… - Neuro …, 2021 - academic.oup.com
Background Chemotherapy improves overall survival after surgery and radiotherapy for
newly diagnosed high-risk IDH-mutant low-grade gliomas (LGGs), but a proportion of …

Immunotherapy approaches for adult glioma: knowledge gained from recent clinical trials

BM Andersen, DA Reardon - Current Opinion in Neurology, 2022 - journals.lww.com
Immunotherapy approaches for adult glioma: knowledge gained... : Current Opinion in
Neurology Immunotherapy approaches for adult glioma: knowledge gained from recent …

Pediatric and adult low-grade gliomas: where do the differences lie?

L Greuter, R Guzman, J Soleman - Children, 2021 - mdpi.com
Two thirds of pediatric gliomas are classified as low-grade (LGG), while in adults only
around 20% of gliomas are low-grade. However, these tumors do not only differ in their …

Role of CX3CR1 signaling in malignant transformation of gliomas

S Lee, K Latha, G Manyam, Y Yang, A Rao… - Neuro …, 2020 - academic.oup.com
Background Chemokine signaling may contribute to progression of low-grade gliomas
(LGGs) by altering tumor behavior or impacting the tumor microenvironment. In this study …

Characterization and clinical implications of different malignant transformation patterns in diffuse low‐grade gliomas

H Jiang, Q Zhu, X Wang, M Li, S Shen, C Yang… - Cancer …, 2023 - Wiley Online Library
Malignant transformation (MT) of low‐grade gliomas (LGGs) to a higher‐grade variant
seems inevitable, yet it remains unclear which LGG patients will progress to grade 3 or even …

Overcoming chemotherapy resistance in low-grade gliomas: A computational approach

T Delobel, LE Ayala-Hernández… - PLoS computational …, 2023 - journals.plos.org
Low-grade gliomas are primary brain tumors that arise from glial cells and are usually
treated with temozolomide (TMZ) as a chemotherapeutic option. They are often incurable …

Association of high‐dose radiotherapy with improved survival in patients with newly diagnosed low‐grade gliomas

Y Liu, S Liu, G Li, Y Li, L Chen, J Feng, Y Yang… - Cancer, 2022 - Wiley Online Library
Background The radiation dose for patients with low‐grade gliomas (LGGs) is controversial.
The objective of this study was to investigate the impact of the radiation dose on survival for …