Trials and tribulations of CETP inhibitors
AR Tall, DJ Rader - Circulation research, 2018 - Am Heart Assoc
The development of CETP (cholesteryl ester transfer protein) inhibitors has had a long and
difficult course with 3 compounds failing in phase III clinical trials. Finally, the REVEAL …
difficult course with 3 compounds failing in phase III clinical trials. Finally, the REVEAL …
Unraveling the complexities of the HDL lipidome1
A Kontush, M Lhomme, MJ Chapman - Journal of lipid research, 2013 - ASBMB
Plasma high density lipoproteins (HDL) are small, dense, protein-rich particles compared
with other lipoprotein classes; roughly half of total HDL mass is accounted for by lipid …
with other lipoprotein classes; roughly half of total HDL mass is accounted for by lipid …
Plasma cholesteryl ester transfer protein
AR Tall - Journal of lipid research, 1993 - Elsevier
The plasma lipoproteins are continuously remodeled during their transit through the plasma
compartment, owing to the action of lipid metabolizing enzymes and lipid transfer processes …
compartment, owing to the action of lipid metabolizing enzymes and lipid transfer processes …
Prevalence of metabolic syndrome in an urban population: Tehran Lipid and Glucose Study
The aim of the present investigation was to determine the prevalence of the metabolic
syndrome among 10 368 of the adults (4397 men and 5971 women) aged 20 years and …
syndrome among 10 368 of the adults (4397 men and 5971 women) aged 20 years and …
The amphipathic α helix: a multifunctional structural motif in plasma apolipoproteins
JP Segrest, DW Garber, CG Brouillette… - Advances in protein …, 1994 - Elsevier
Publisher Summary The dominant structural motif of the peripheral apolipoproteins is the
amphipathic helix, which is responsible for the reversible association of these proteins with …
amphipathic helix, which is responsible for the reversible association of these proteins with …
Association of Cholesteryl Ester Transfer Protein–TaqIB Polymorphism With Variations in Lipoprotein Subclasses and Coronary Heart Disease Risk: The Framingham …
Cholesteryl ester transfer protein (CETP) facilitates the exchange of triglycerides and
cholesteryl esters between lipoprotein particles, a key step in reverse cholesterol transport in …
cholesteryl esters between lipoprotein particles, a key step in reverse cholesterol transport in …
High density lipoproteins (HDLs) and atherosclerosis; the unanswered questions
The concentration of high density lipoprotein-cholesterol (HDL-C) has been found
consistently to be a powerful negative predictor of premature coronary heart disease (CHD) …
consistently to be a powerful negative predictor of premature coronary heart disease (CHD) …
Raising high-density lipoprotein in humans through inhibition of cholesteryl ester transfer protein: an initial multidose study of torcetrapib
RW Clark, TA Sutfin, RB Ruggeri… - … , and vascular biology, 2004 - Am Heart Assoc
Objective—The ability of the potent cholesteryl ester transfer protein (CETP) inhibitor
torcetrapib (CP-529,414) to raise high-density lipoprotein cholesterol (HDL-C) levels in …
torcetrapib (CP-529,414) to raise high-density lipoprotein cholesterol (HDL-C) levels in …
Plasma lipid transfer proteins.
A Tall - Annual review of biochemistry, 1995 - europepmc.org
The plasma lipid transfer proteins mediate the transfer and exchange of phospholipids and
neutral lipids between the plasma lipoproteins. The cholesteryl ester transfer protein (CETP) …
neutral lipids between the plasma lipoproteins. The cholesteryl ester transfer protein (CETP) …
Plasma lipid transfer proteins, high-density lipoproteins, and reverse cholesterol transport
▪ Abstract Cholesteryl ester transfer protein (CETP) and phospholipid transfer protein (PLTP)
are members of the lipid transfer/lipopolysaccharide binding protein gene family. Recently …
are members of the lipid transfer/lipopolysaccharide binding protein gene family. Recently …