Mesenchymal stem cells for neurological disorders

A Andrzejewska, S Dabrowska, B Lukomska… - Advanced …, 2021 - Wiley Online Library
Neurological disorders are becoming a growing burden as society ages, and there is a
compelling need to address this spiraling problem. Stem cell‐based regenerative medicine …

Mesenchymal stem cells in treatment of spinal cord injury and amyotrophic lateral sclerosis

E Sykova, D Cizkova, S Kubinova - Frontiers in cell and …, 2021 - frontiersin.org
Preclinical and clinical studies with various stem cells, their secretomes, and extracellular
vesicles (EVs) indicate their use as a promising strategy for the treatment of various …

A comparative analysis of multipotent mesenchymal stromal cells derived from different sources, with a focus on neuroregenerative potential

Y Petrenko, I Vackova, K Kekulova, M Chudickova… - Scientific reports, 2020 - nature.com
Multipotent mesenchymal stromal cells (MSCs) can be considered an accessible therapeutic
tool for regenerative medicine. Here, we compared the growth kinetics, immunophenotypic …

Mesenchymal stem/stromal cells derived from human and animal perinatal tissues—origins, characteristics, signaling pathways, and clinical trials

M Kulus, R Sibiak, K Stefańska, M Zdun… - Cells, 2021 - mdpi.com
Mesenchymal stem/stromal cells (MSCs) are currently one of the most extensively
researched fields due to their promising opportunity for use in regenerative medicine. There …

[HTML][HTML] Mesenchymal stem cell secretome and extracellular vesicles for neurodegenerative diseases: Risk-benefit profile and next steps for the market access

L Giovannelli, E Bari, C Jommi, F Tartara, D Armocida… - Bioactive Materials, 2023 - Elsevier
Neurodegenerative diseases represent a growing burden on healthcare systems worldwide.
Mesenchymal stem cells (MSCs) have shown promise as a potential therapy due to their …

[HTML][HTML] Advanced approaches to regenerate spinal cord injury: the development of cell and tissue engineering therapy and combinational treatments

J Saremi, N Mahmoodi, M Rasouli, FE Ranjbar… - Biomedicine & …, 2022 - Elsevier
Spinal cord injury (SCI) is a central nervous system (CNS) devastate event that is commonly
caused by traumatic or non-traumatic events. The reinnervation of spinal cord axons is …

Regenerative potential of Wharton's jelly‐derived mesenchymal stem cells: A new horizon of stem cell therapy

H Abbaszadeh, F Ghorbani… - Journal of Cellular …, 2020 - Wiley Online Library
Umbilical cord Wharton's jelly‐derived mesenchymal stem cells (WJ‐MSCs) have recently
gained considerable attention in the field of regenerative medicine. Their high proliferation …

Human Wharton's jelly—cellular specificity, stemness potency, animal models, and current application in human clinical trials

K Stefańska, K Ożegowska, G Hutchings… - Journal of Clinical …, 2020 - mdpi.com
Stem cell therapies offer a great promise for regenerative and reconstructive medicine, due
to their self-renewal and differentiation capacity. Although embryonic stem cells are …

Exosomes derived from human placenta-derived mesenchymal stem cells improve neurologic function by promoting angiogenesis after spinal cord injury

C Zhang, CL Zhang, Y Xu, C Li, Y Cao, P Li - Neuroscience Letters, 2020 - Elsevier
Background Spinal cord injury (SCI) is a serious central nervous system condition with no
effective clinal treatment. Recently, transplantation of bone marrow mesenchymal stem cells …

Schwann cell-like cells: origin and usability for repair and regeneration of the peripheral and central nervous system

A Hopf, DJ Schaefer, DF Kalbermatten, R Guzman… - Cells, 2020 - mdpi.com
Functional recovery after neurotmesis, a complete transection of the nerve fiber, is often poor
and requires a surgical procedure. Especially for longer gaps (> 3 mm), end-to-end suturing …