Therapeutic strategies targeting FOXO transcription factors
FOXO proteins are transcription factors that are involved in numerous physiological
processes and in various pathological conditions, including cardiovascular disease, cancer …
processes and in various pathological conditions, including cardiovascular disease, cancer …
FOXO transcription factor family in cancer and metastasis
Y Jiramongkol, EWF Lam - Cancer and Metastasis Reviews, 2020 - Springer
Forkhead box O (FOXO) transcription factors regulate diverse biological processes, affecting
development, metabolism, stem cell maintenance and longevity. They have also been …
development, metabolism, stem cell maintenance and longevity. They have also been …
Lysine acetylation goes global: from epigenetics to metabolism and therapeutics
Post-translational acetylation of lysine residues has emerged as a key regulatory
mechanism in all eukaryotic organisms. Originally discovered in 1963 as a unique …
mechanism in all eukaryotic organisms. Originally discovered in 1963 as a unique …
AMPK–SKP2–CARM1 signalling cascade in transcriptional regulation of autophagy
Autophagy is a highly conserved self-digestion process, which is essential for maintaining
homeostasis and viability in response to nutrient starvation,,,. Although the components of …
homeostasis and viability in response to nutrient starvation,,,. Although the components of …
The foxo code
Abstract The FoxO family of Forkhead transcription factors plays an important role in
longevity and tumor suppression by upregulating target genes involved in stress resistance …
longevity and tumor suppression by upregulating target genes involved in stress resistance …
Cellular and molecular biology of aging endothelial cells
Cardiovascular disease (CVD) is the leading cause of death in the United States and aging
is a major risk factor for CVD development. One of the major age-related arterial phenotypes …
is a major risk factor for CVD development. One of the major age-related arterial phenotypes …
Hsa_circRNA_103809 regulated the cell proliferation and migration in colorectal cancer via miR-532–3p/FOXO4 axis
L Bian, X Zhi, L Ma, J Zhang, P Chen, S Sun, J Li… - Biochemical and …, 2018 - Elsevier
Circular RNAs (circRNAs) are a class of non-coding RNAs that are widely expressed in a
variety of cell species. The role they play in cancers is poorly understood, especially in …
variety of cell species. The role they play in cancers is poorly understood, especially in …
TF-DUBTACs stabilize tumor suppressor transcription factors
Targeted protein degradation approaches have been widely used for degrading oncogenic
proteins, providing a potentially promising therapeutic strategy for cancer treatment …
proteins, providing a potentially promising therapeutic strategy for cancer treatment …
Forkhead transcription factors: key players in health and disease
Forkhead box (FOX) proteins constitute an evolutionarily conserved family of transcription
factors with a central role not only during development, but also in the adult organism. Thus …
factors with a central role not only during development, but also in the adult organism. Thus …
Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt
K Yamagata, H Daitoku, Y Takahashi, K Namiki… - Molecular cell, 2008 - cell.com
Forkhead box O (FOXO) transcription factors, the key regulators of cell survival, are
negatively controlled through the PI3K-Akt signaling pathway. Phosphorylation of FOXO by …
negatively controlled through the PI3K-Akt signaling pathway. Phosphorylation of FOXO by …