The ability of chemical modifications of single nucleotides to alter the electrostatic charge,
hydrophobic surface and base pairing of RNA molecules is exploited for the clinical use of …

Adult stem cells are important for mammalian tissues, where they act as a cell reserve that
supports normal tissue turnover and can mount a regenerative response following acute …

Transcription factors (TFs) regulate gene programs, thereby controlling diverse cellular
processes and cell states. To comprehensively understand TFs and the programs they …

The mammalian brain is complex, with multiple cell types performing a variety of diverse
functions, but exactly how each cell type is affected in aging remains largely unknown. Here …

RNA modifications have recently emerged as critical posttranscriptional regulators of gene
expression programs. They affect diverse eukaryotic biological processes, and the correct …

Neural stem cells (NSCs) generate new neurons throughout life in the mammalian brain.
Adult-born neurons shape brain function, and endogenous NSCs could potentially be …

The mammalian brain contains neurogenic niches that comprise neural stem cells and other
cell types. Neurogenic niches become less functional with age, but how they change during …

Many patients with advanced cancers achieve dramatic responses to a panoply of
therapeutics yet retain minimal residual disease (MRD), which ultimately results in relapse …

Quiescence is a state of reversible proliferative arrest in which cells are not actively dividing
and yet retain the capacity to reenter the cell cycle upon receiving an appropriate stimulus …

Methods for quantifying gene expression and chromatin accessibility in single cells are well
established, but single-cell analysis of chromatin regions with specific histone modifications …