Cells have the ability to respond to various types of environmental cues, and in many cases
these cues induce directed cell migration towards or away from these signals. How cells …

Actin dynamics in cell motility, division, and phagocytosis is regulated by complex factors
with multiple feedback loops, often leading to emergent dynamic patterns in the form of …

During cell migration and polarization, numerous signal transduction and cytoskeletal
components self-organize to generate localized protrusions. Although biochemical and …

Drug discovery is important in cancer therapy and precision medicines. Traditional
approaches of drug discovery are mainly based on in vivo animal experiments and in vitro …

Ras has been extensively studied as a promoter of cell proliferation, whereas few studies
have explored its role in migration. To investigate the direct and immediate effects of Ras …

Although directed migration of eukaryotic cells may have evolved to escape nutrient
depletion, it has been adopted for an extensive range of physiological events during …

As the metabolic and detoxification center of the body, the liver is closely involved in many
critical physiological processes, such as metabolism, immunity, digestion, storage of liver …

Macropinocytosis is a conserved endocytic process by which cells engulf droplets of
medium into micron-sized vesicles. We use light-sheet microscopy to define an underlying …

Summary The Ras/PI3K/extracellular signal-regulated kinases (ERK) signaling network
plays fundamental roles in cell growth, survival, and migration and is frequently activated in …

The actin cytoskeleton is indispensable for several cellular processes, including migration,
morphogenesis, polarized growth, endocytosis, and phagocytosis. The organization and …