Role of JAK-STAT and PPAR-gamma signalling modulators in the prevention of autism and neurological dysfunctions

R Khera, S Mehan, S Kumar, P Sethi, S Bhalla… - Molecular …, 2022 - Springer
The Janus-kinase (JAK) and signal transducer activator of transcription (STAT) signalling
pathways regulate gene expression and control various factors involved in normal …

Autism spectrum disorder: signaling pathways and prospective therapeutic targets

J Baranova, G Dragunas, MCS Botellho… - Cellular and molecular …, 2021 - Springer
Abstract The Autism Spectrum Disorder (ASD) consists of a prevalent and heterogeneous
group of neurodevelopmental diseases representing a severe burden to affected individuals …

Therapeutic modulation of JAK-STAT, mTOR, and PPAR-γ signaling in neurological dysfunctions

S Kumar, S Mehan, AS Narula - Journal of Molecular Medicine, 2023 - Springer
The cytokine-activated Janus kinase (JAK)–signal transducer and activator of transcription
(STAT) cascade is a pleiotropic pathway that involves receptor subunit multimerization. The …

A potent and selective CXCR2 antagonist improves neuroimmune dysregulation through the inhibition of NF-κB and notch inflammatory signaling in the BTBR mouse …

HA Alomar, MA Ansari, A Nadeem, SM Attia… - Journal of …, 2023 - Elsevier
Autism comprises a broad range of neurodevelopmental disorders characterized by social
communication deficits and repetitive and stereotyped behaviors. Chemokine receptor …

Association of infant feeding indicators and infant feeding practices with coexisting forms of malnutrition in children under six months of age

A Khaliq, D Wraith, Y Miller, S Nambiar - Nutrients, 2022 - mdpi.com
Breastmilk is the only recommended source of nutrition for infants below six months of age.
However, a significant proportion of children are either on supplemental breastfeeding (SBF) …

The Exposure to Lead (Pb) Exacerbates Immunological Abnormalities in BTBR T+ Itpr3tf/J Mice through the Regulation of Signaling Pathways Relevant to T Cells

MA Assiri, TH Albekairi, MA Ansari, A Nadeem… - International Journal of …, 2023 - mdpi.com
Autism spectrum disorder (ASD) is a common neurodevelopmental illness characterized by
abnormal social interactions, communication difficulties, and repetitive and limited behaviors …

Aflatoxin B1 Exposure Aggravates Neurobehavioral Deficits and Immune Dysfunctions of Th1, Th9, Th17, Th22, and T Regulatory Cell-Related Transcription Factor Signaling in the BTBR T …

MY Alwetaid, TN Almanaa, SA Bakheet, MA Ansari… - Brain Sciences, 2023 - mdpi.com
Autism spectrum disorder (ASD) is a neurodevelopmental disease characterized by
impaired communication, reciprocal social interactions, restricted sociability deficits, and …

Protease-activated receptor-1 antagonist protects against lung ischemia/reperfusion injury

SJ Chu, SE Tang, HP Pao, SY Wu… - Frontiers in Pharmacology, 2021 - frontiersin.org
Protease-activated receptor (PAR)-1 is a thrombin-activated receptor that plays an essential
role in ischemia/reperfusion (IR)-induced acute inflammation. PAR-1 antagonists have been …

Integrated microRNA–mRNA Expression Profiling Identifies Novel Targets and Networks Associated with Autism

PS Gill, H Dweep, S Rose, PJ Wickramasinghe… - Journal of Personalized …, 2022 - mdpi.com
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder, with mutations
in hundreds of genes contributing to its risk. Herein, we studied lymphoblastoid cell lines …

Immunomodulatory role of spleen tyrosine kinase in chronic inflammatory and autoimmune diseases

Y Zhou, Y Zhang, W Yu, Y Qin, H He… - Immunity …, 2023 - Wiley Online Library
Background The high prevalence of chronic inflammatory diseases or autoimmune reactions
is a major source of concern and affects the quality of life of patients. Chronic inflammatory …