Role of JAK-STAT and PPAR-gamma signalling modulators in the prevention of autism and neurological dysfunctions
The Janus-kinase (JAK) and signal transducer activator of transcription (STAT) signalling
pathways regulate gene expression and control various factors involved in normal …
pathways regulate gene expression and control various factors involved in normal …
Autism spectrum disorder: signaling pathways and prospective therapeutic targets
J Baranova, G Dragunas, MCS Botellho… - Cellular and molecular …, 2021 - Springer
Abstract The Autism Spectrum Disorder (ASD) consists of a prevalent and heterogeneous
group of neurodevelopmental diseases representing a severe burden to affected individuals …
group of neurodevelopmental diseases representing a severe burden to affected individuals …
Therapeutic modulation of JAK-STAT, mTOR, and PPAR-γ signaling in neurological dysfunctions
S Kumar, S Mehan, AS Narula - Journal of Molecular Medicine, 2023 - Springer
The cytokine-activated Janus kinase (JAK)–signal transducer and activator of transcription
(STAT) cascade is a pleiotropic pathway that involves receptor subunit multimerization. The …
(STAT) cascade is a pleiotropic pathway that involves receptor subunit multimerization. The …
A potent and selective CXCR2 antagonist improves neuroimmune dysregulation through the inhibition of NF-κB and notch inflammatory signaling in the BTBR mouse …
Autism comprises a broad range of neurodevelopmental disorders characterized by social
communication deficits and repetitive and stereotyped behaviors. Chemokine receptor …
communication deficits and repetitive and stereotyped behaviors. Chemokine receptor …
Association of infant feeding indicators and infant feeding practices with coexisting forms of malnutrition in children under six months of age
Breastmilk is the only recommended source of nutrition for infants below six months of age.
However, a significant proportion of children are either on supplemental breastfeeding (SBF) …
However, a significant proportion of children are either on supplemental breastfeeding (SBF) …
The Exposure to Lead (Pb) Exacerbates Immunological Abnormalities in BTBR T+ Itpr3tf/J Mice through the Regulation of Signaling Pathways Relevant to T Cells
Autism spectrum disorder (ASD) is a common neurodevelopmental illness characterized by
abnormal social interactions, communication difficulties, and repetitive and limited behaviors …
abnormal social interactions, communication difficulties, and repetitive and limited behaviors …
Aflatoxin B1 Exposure Aggravates Neurobehavioral Deficits and Immune Dysfunctions of Th1, Th9, Th17, Th22, and T Regulatory Cell-Related Transcription Factor Signaling in the BTBR T …
MY Alwetaid, TN Almanaa, SA Bakheet, MA Ansari… - Brain Sciences, 2023 - mdpi.com
Autism spectrum disorder (ASD) is a neurodevelopmental disease characterized by
impaired communication, reciprocal social interactions, restricted sociability deficits, and …
impaired communication, reciprocal social interactions, restricted sociability deficits, and …
Protease-activated receptor-1 antagonist protects against lung ischemia/reperfusion injury
SJ Chu, SE Tang, HP Pao, SY Wu… - Frontiers in Pharmacology, 2021 - frontiersin.org
Protease-activated receptor (PAR)-1 is a thrombin-activated receptor that plays an essential
role in ischemia/reperfusion (IR)-induced acute inflammation. PAR-1 antagonists have been …
role in ischemia/reperfusion (IR)-induced acute inflammation. PAR-1 antagonists have been …
Integrated microRNA–mRNA Expression Profiling Identifies Novel Targets and Networks Associated with Autism
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder, with mutations
in hundreds of genes contributing to its risk. Herein, we studied lymphoblastoid cell lines …
in hundreds of genes contributing to its risk. Herein, we studied lymphoblastoid cell lines …
Immunomodulatory role of spleen tyrosine kinase in chronic inflammatory and autoimmune diseases
Y Zhou, Y Zhang, W Yu, Y Qin, H He… - Immunity …, 2023 - Wiley Online Library
Background The high prevalence of chronic inflammatory diseases or autoimmune reactions
is a major source of concern and affects the quality of life of patients. Chronic inflammatory …
is a major source of concern and affects the quality of life of patients. Chronic inflammatory …