Forming the inner layer of the vascular system, endothelial cells (ECs) facilitate a multitude
of crucial physiological processes throughout the body. Vascular ECs enable the vessel wall …

The choroid plexus epithelium is a cuboidal cell monolayer, which produces the majority of
the cerebrospinal fluid. The concerted action of a variety of integral membrane proteins …

Spatial transcriptomics are a collection of genomic technologies that have enabled
transcriptomic profiling on tissues with spatial localization information. Analyzing spatial …

Microglia, the brain-resident macrophages, exhibit highly dynamic functions in
neurodevelopment and neurodegeneration. Human microglia possess unique features as …

Specialized niches support the lifelong maintenance and function of tissue-specific stem
cells. Adult neural stem cells in the ventricular-subventricular zone (V-SVZ) contact the …

The aging process correlates with a progressive failure in the normal cellular and organ
functioning; these alterations are aggravated in Alzheimer's disease (AD). In both aging and …

Although many features of neurogenesis during development and in the adult are intrinsic to
the neurogenic cells themselves, the role of the microenvironment is irrefutable. The …

Mammalian circadian clocks have a hierarchical organization, governed by the
suprachiasmatic nucleus (SCN) in the hypothalamus. The brain itself contains multiple loci …

Adult neurogenesis has been convincingly demonstrated in two regions of the mammalian
brain: the sub-granular zone (SGZ) of the dentate gyrus (DG) in the hippocampus, and the …

Barrier mechanisms in the brain are important for its normal functioning and development.
Stability of the brain's internal environment, particularly with respect to its ionic composition …