An appropriate response and adaptation to hyperosmolarity, ie., an external osmolarity that
is higher than the physiological range, can be a matter of life or death for all cells. It is …

The cyclin dependent kinase Cdk1 controls the cell cycle, which is best understood in the
model organism S. cerevisiae. Research performed during the past decade has significantly …

Size homeostasis in budding yeast requires that cells grow to a critical size before
commitment to division in the late prereplicative growth phase of the cell cycle, an event …

Many disease states result from gene overexpression, often in a specific genetic context. To
explore gene overexpression phenotypes systematically, we assembled an array of 5280 …

RNA-binding proteins (RBPs) have roles in the regulation of many post-transcriptional steps
in gene expression, but relatively few RBPs have been systematically studied. We searched …

Cells of a given type maintain a characteristic cell size to function efficiently in their
ecological or organismal context. They achieve this through the regulation of growth rates or …

Budding yeast cells are assumed to trigger Start and enter the cell cycle only after they attain
a critical size set by external conditions. However, arguing against deterministic models of …

Cellular behavior is frequently influenced by the cell's history, indicating that single cells may
memorize past events. We report that budding yeast permanently escape pheromone …

In the budding yeast, Saccharomyces cerevisiae, a significant fraction of genes (> 10%) are
transcribed with cell cycle periodicity. These genes encode critical cell cycle regulators as …

In budding yeast cells, nutrient repletion induces rapid exit from quiescence and entry into a
round of growth and division. The G1 cyclin CLN3 is one of the earliest genes activated in …