[HTML][HTML] The phylogenomics of evolving virus virulence
JL Geoghegan, EC Holmes - Nature Reviews Genetics, 2018 - nature.com
How virulence evolves after a virus jumps to a new host species is central to disease
emergence. Our current understanding of virulence evolution is based on insights drawn …
emergence. Our current understanding of virulence evolution is based on insights drawn …
Virulence and pathogenesis of HIV-1 infection: an evolutionary perspective
Background Why some individuals develop AIDS rapidly whereas others remain healthy
without treatment for many years remains a central question of HIV research. Of the …
without treatment for many years remains a central question of HIV research. Of the …
A highly virulent variant of HIV-1 circulating in the Netherlands
We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred
nine individuals with this variant had a 0.54 to 0.74 log10 increase (ie, a~ 3.5-fold to 5.5-fold …
nine individuals with this variant had a 0.54 to 0.74 log10 increase (ie, a~ 3.5-fold to 5.5-fold …
[HTML][HTML] Estimating the impact of antiretroviral treatment on adult mortality trends in South Africa: A mathematical modelling study
Background Substantial reductions in adult mortality have been observed in South Africa
since the mid-2000s, but there has been no formal evaluation of how much of this decline is …
since the mid-2000s, but there has been no formal evaluation of how much of this decline is …
What is a pathogen? Toward a process view of host-parasite interactions
PO Méthot, S Alizon - Virulence, 2014 - Taylor & Francis
Until quite recently and since the late 19th century, medical microbiology has been based on
the assumption that some micro-organisms are pathogens and others are not. This binary …
the assumption that some micro-organisms are pathogens and others are not. This binary …
The impact of host genetic variation on infection with HIV-1
PJ McLaren, M Carrington - Nature immunology, 2015 - nature.com
The outcome after infection with the human immunodeficiency virus type 1 (HIV-1) is a
complex phenotype determined by interactions among the pathogen, the human host and …
complex phenotype determined by interactions among the pathogen, the human host and …
Impact of HLA-driven HIV adaptation on virulence in populations of high HIV seroprevalence
It is widely believed that epidemics in new hosts diminish in virulence over time, with natural
selection favoring pathogens that cause minimal disease. However, a tradeoff frequently …
selection favoring pathogens that cause minimal disease. However, a tradeoff frequently …
[HTML][HTML] Controlling long-term SARS-CoV-2 infections can slow viral evolution and reduce the risk of treatment failure
D Van Egeren, A Novokhodko, M Stoddard, U Tran… - Scientific reports, 2021 - nature.com
The rapid emergence and expansion of novel SARS-CoV-2 variants threatens our ability to
achieve herd immunity for COVID-19. These novel SARS-CoV-2 variants often harbor …
achieve herd immunity for COVID-19. These novel SARS-CoV-2 variants often harbor …
HIV-1 adaptation to HLA: a window into virus–host immune interactions
HIV-1 develops specific mutations within its genome that allow it to escape detection by
human leukocyte antigen (HLA) class I-restricted immune responses, notably those of CD8+ …
human leukocyte antigen (HLA) class I-restricted immune responses, notably those of CD8+ …
[HTML][HTML] A transmission-virulence evolutionary trade-off explains attenuation of HIV-1 in Uganda
Evolutionary theory hypothesizes that intermediate virulence maximizes pathogen fitness as
a result of a trade-off between virulence and transmission, but empirical evidence remains …
a result of a trade-off between virulence and transmission, but empirical evidence remains …