Cellular and molecular pathobiology of heart failure with preserved ejection fraction

S Mishra, DA Kass - Nature Reviews Cardiology, 2021 - nature.com
Heart failure with preserved ejection fraction (HFpEF) affects half of all patients with heart
failure worldwide, is increasing in prevalence, confers substantial morbidity and mortality …

Inflammation in Heart Failure: JACC State-of-the-Art Review

SP Murphy, R Kakkar, CP McCarthy… - Journal of the American …, 2020 - jacc.org
It has long been observed that heart failure (HF) is associated with measures of systemic
inflammation. In recent years, there have been significant advancements in our …

How to diagnose heart failure with preserved ejection fraction: the HFA–PEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association …

B Pieske, C Tschöpe, RA De Boer… - European heart …, 2019 - academic.oup.com
Making a firm diagnosis of chronic heart failure with preserved ejection fraction (HFpEF)
remains a challenge. We recommend a new stepwise diagnostic process, the 'HFA–PEFF …

Coronary microvascular dysfunction

F Vancheri, G Longo, S Vancheri, M Henein - Journal of Clinical …, 2020 - mdpi.com
Many patients with chest pain undergoing coronary angiography do not show significant
obstructive coronary lesions. A substantial proportion of these patients have abnormalities in …

Diffuse myocardial fibrosis: mechanisms, diagnosis and therapeutic approaches

B López, S Ravassa, MU Moreno, GS José… - Nature Reviews …, 2021 - nature.com
Diffuse myocardial fibrosis resulting from the excessive deposition of collagen fibres through
the entire myocardium is encountered in a number of chronic cardiac diseases. This lesion …

Research priorities for heart failure with preserved ejection fraction: national heart, lung, and blood institute working group summary

SJ Shah, BA Borlaug, DW Kitzman, AD McCulloch… - Circulation, 2020 - Am Heart Assoc
Heart failure with preserved ejection fraction (HFpEF), a major public health problem that is
rising in prevalence, is associated with high morbidity and mortality and is considered to be …

Myocardial metabolomics of human heart failure with preserved ejection fraction

VS Hahn, C Petucci, MS Kim, KC Bedi Jr, H Wang… - Circulation, 2023 - Am Heart Assoc
Background: The human heart primarily metabolizes fatty acids, and this decreases as
alternative fuel use rises in heart failure with reduced ejection fraction (HFrEF). Patients with …

Cellular and molecular differences between HFpEF and HFrEF: a step ahead in an improved pathological understanding

SJ Simmonds, I Cuijpers, S Heymans, EAV Jones - Cells, 2020 - mdpi.com
Heart failure (HF) is the most rapidly growing cardiovascular health burden worldwide. HF
can be classified into three groups based on the percentage of the ejection fraction (EF) …

Endomyocardial biopsy characterization of heart failure with preserved ejection fraction and prevalence of cardiac amyloidosis

VS Hahn, LR Yanek, J Vaishnav, W Ying, D Vaidya… - Heart failure, 2020 - jacc.org
Objectives This study prospectively evaluated endomyocardial biopsies in patients with
heart failure with preserved ejection fraction (HFpEF) to identify histopathologic phenotypes …

Myocardial gene expression signatures in human heart failure with preserved ejection fraction

VS Hahn, H Knutsdottir, X Luo, K Bedi, KB Margulies… - Circulation, 2021 - Am Heart Assoc
Background: Heart failure (HF) with preserved ejection fraction (HFpEF) constitutes half of all
HF but lacks effective therapy. Understanding of its myocardial biology remains limited …