The cumulative impact of chronic inflammation in patients with inflammatory bowel diseases
predisposes to the development of inflammatory bowel disease-associated colorectal …

Colorectal cancer (CRC) is one of the leading causes of cancer-related death in the world.
Besides genetic causes, colonic inflammation is one of the major risk factors for CRC …

Microbiota play critical roles in regulating colitis and colorectal cancer (CRC). However, it is
unclear how the microbiota generate protective immunity against these disease states. Here …

Crimean-Congo hemorrhagic fever virus (CCHFV) is the most widespread tick-born zoonotic
bunyavirus that causes severe hemorrhagic fever and death in humans. CCHFV enters the …

Regulatory T cells (Treg cells) are instrumental in establishing immunological tolerance.
However, the precise effector mechanisms by which Treg cells control a specific type of …

Over the past decades, tumor-resident immune cells have been extensively studied to
dissect their biological functions and clinical roles. Tumor-infiltrating CD8+ T cells, because …

Animal models for colitis-associated colorectal cancer (CACC) represent an important tool to
explore the mechanistic basis of cancer-related inflammation, providing important evidence …

Colorectal cancer (CRC) is the third most common cancer worldwide. One of the main
causes of colorectal cancer is inflammatory bowel disease (IBD), which includes ulcerative …

Head and neck squamous cell carcinoma (HNSCC) still lacks effective targeted treatment.
Therefore, exploring novel and robust molecular targets is critical for improving the clinical …

Aberrant microbe-immune cell interaction is a predisposing factor in inflammatory bowel
disease (IBD) and colitis-associated cancer (CAC). Cortex Periplocae is a famous traditional …