Current understanding of immunity to Trypanosoma cruzi infection and pathogenesis of Chagas disease
Chagas disease caused by Trypanosoma cruzi remains an important neglected tropical
disease and a cause of significant morbidity and mortality. No longer confined to endemic …
disease and a cause of significant morbidity and mortality. No longer confined to endemic …
Interferon-γ: biology and role in pathogenesis
A Billiau - Advances in immunology, 1996 - Elsevier
Publisher Summary The chapter focuses on the salient issues and most recent advances
concerning IFN-γ's biological function to provide a framework for understanding its role in …
concerning IFN-γ's biological function to provide a framework for understanding its role in …
Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite
Glycosylphosphatidylinositol (GPI) anchors and glycoinositolphospholipids (GIPLs) from
parasitic protozoa have been shown to exert a wide variety of effects on cells of the host …
parasitic protozoa have been shown to exert a wide variety of effects on cells of the host …
Antigen presentation by cardiac fibroblasts promotes cardiac dysfunction
Heart failure (HF) is a leading cause of morbidity and mortality. Studies in animal models
and individuals with HF revealed a prominent role for CD4+ T cell immune responses in the …
and individuals with HF revealed a prominent role for CD4+ T cell immune responses in the …
The unsolved jigsaw puzzle of the immune response in Chagas disease
GR Acevedo, MC Girard, KA Gómez - Frontiers in immunology, 2018 - frontiersin.org
Trypanosoma cruzi interacts with the different arms of the innate and adaptive host's immune
response in a very complex and flowery manner. The history of host-parasite co-evolution …
response in a very complex and flowery manner. The history of host-parasite co-evolution …
Immnunological Control of Trypanosoma cruzi Infection and Pathogenesis of Chagas' Disease
Z Brener, RT Gazzinelli - International archives of allergy and …, 1997 - karger.com
The major goal of studies on immunity to Trypanosoma cruzi is the understanding of
immunological mechanisms involved in resistance to this protozoan as well as the …
immunological mechanisms involved in resistance to this protozoan as well as the …
Intraphagosomal peroxynitrite as a macrophage-derived cytotoxin against internalized Trypanosoma cruzi: consequences for oxidative killing and role of microbial …
MN Alvarez, G Peluffo, L Piacenza, R Radi - Journal of Biological Chemistry, 2011 - ASBMB
Macrophage-derived radicals generated by the NADPH oxidase complex and inducible
nitric-oxide synthase (iNOS) participate in cytotoxic mechanisms against microorganisms …
nitric-oxide synthase (iNOS) participate in cytotoxic mechanisms against microorganisms …
IL-6 promotes NK cell production of IL-17 during toxoplasmosis
Previous studies have implicated T cell production of IL-17 in resistance to Toxoplasma
gondii as well as the development of immune-mediated pathology during this infection …
gondii as well as the development of immune-mediated pathology during this infection …
Whatever turns you on: accessory-cell-dependent activation of NK cells by pathogens
KC Newman, EM Riley - Nature Reviews Immunology, 2007 - nature.com
Natural killer (NK) cells have a crucial role in combating infections and cancers and their
surface receptors can directly recognize and respond to damaged, transformed or non-self …
surface receptors can directly recognize and respond to damaged, transformed or non-self …
Interleukin-12 mediates resistance to Trypanosoma cruzi in mice and is produced by murine macrophages in response to live trypomastigotes
JC Aliberti, MA Cardoso, GA Martins… - Infection and …, 1996 - Am Soc Microbiol
Host resistance to infection by Trypanosoma cruzi is dependent on both natural and
acquired immune responses. During the first week of infection in mice, NK cell-derived …
acquired immune responses. During the first week of infection in mice, NK cell-derived …