Nine new fluorine-containing drugs have been approved by the US Food and Drug
Administration (FDA) in 2021, which are presented in this review article. These small …

This review describes the recent Food and Drug Administration (FDA)-approved drugs (in
the year 2021) containing at least one halogen atom (covalently bound). The structures …

During the last twenty years, organic fluorination chemistry established itself as an important
tool to get a biologically active compound. This belief can be supported by the fact that every …

Resonance‐assisted hydrogen bonding (RAHB), a concept introduced by Gilli and co‐
workers in 1989, concerns a kind of intramolecular H‐bonding strengthened by a …

Dolutegravir (DTG), an important active pharmaceutical ingredient (API) used in combination
therapy for the treatment of HIV, has been synthesized in continuous flow. By adapting the …

Bictegravir and dolutegravir are two recently approved integrase inhibitors for the treatment
of HIV. A third inhibitor, cabotegravir, is in Phase 3 development. As a continuation of a …

Abstract Demethylation of DTG-7 (ie, an intermediate of an anti-HIV medication dolutegravir
(DTG)) is the final step in the DTG synthesis, but its reaction network and kinetic …

Application of chemotherapeutic agents to inhibit the HIV replication process has brought
about a significant metamorphosis in the landscape of AIDS. Substantial declines in …

We demonstrate the application of molecular rotational resonance (MRR) spectroscopy to
quantify regioisomeric, dehalogenated, and enantiomeric impurities in two raw materials …

An enantioselective synthesis of diverse N4-Boc-protected α, α-disubstituted piperazin-2-
ones using the palladium-catalyzed decarboxylative allylic alkylation reaction has been …