As an essential component of the maternal-fetal interface, the placental syncytiotrophoblast
layer contributes to a successful pregnancy by secreting hormones necessary for …

The placenta is an important organ for the exchange of substances between the fetus and
the mother, hormone secretion, and fetoplacental immunological defense. Placenta has an …

High-altitude (> 2,500 m) residence increases the risk of pregnancy vascular disorders such
as fetal growth restriction and preeclampsia, each characterized by impaired placental …

Infection-associated pregnancy complications cause premature delivery. Caspase-1 is
involved in the maturation of interleukin (IL)-1β, which is activated by the NLRP3 …

Use of glyburide in gestational diabetes (GDM) has raised concerns about fetal and
neonatal side effects, including increased birth weight. Placental nutrient transport is a key …

Objective Prostaglandins (PGs) function in various reproductive processes, including
luteolysis, maternal pregnancy recognition, conceptus development, and parturition. Our …

Brain contusions (BCs) are one of the most frequent lesions in patients with moderate and
severe traumatic brain injury (TBI). BCs increase their volume due to peri-lesional edema …

Preeclampsia (PE) is a prevalent obstetric complication affecting approximately 3–5% of
pregnancies worldwide and is a major cause of maternal and perinatal morbidity and …

Human chorionic gonadotropin (hCG) is a key autocrine/paracrine regulator of placental
syncytiotrophoblast, the transport epithelium of the human placenta. Syncytiotrophoblast …

Placental trophoblast cells differentiate into invasive trophoblasts or syncytiotrophoblasts.
Abnormal trophoblast invasion results in pregnancy-associated disease and abortion. uPAR …