Biomechanics of chondrocytes and chondrons in healthy conditions and osteoarthritis: a review of the mechanical characterisations at the microscale

S Pettenuzzo, A Arduino, E Belluzzi, A Pozzuoli… - Biomedicines, 2023 - mdpi.com
Biomechanical studies are expanding across a variety of fields, from biomedicine to
biomedical engineering. From the molecular to the system level, mechanical stimuli are …

Finite element models of osteocytes and their load-induced activation

TH Smit - Current Osteoporosis Reports, 2022 - Springer
Abstract Purpose of Review Osteocytes are the conductors of bone adaptation and
remodelling. Buried inside the calcified matrix, they sense mechanical cues and signal …

基于机器学习软骨细胞的时间依赖性力学行为及本构参数反演

魏新宇, 桑建兵, 张睿琳, 王静远, 刘宝友 - 力学学报, 2022 - lxxb.cstam.org.cn
探究软骨细胞机械负载下的力学特性对于理解软骨细胞的正常和病理状态以及骨性关节炎的
病因至关重要. 基于软骨细胞有限元计算模型的力学响应与其本构参数之间的高度复杂非线性 …

Impact of nanoparticle uptake on the biophysical properties of cell for biomedical engineering applications

MAI Rasel, S Singh, TD Nguyen, IO Afara, Y Gu - Scientific Reports, 2019 - nature.com
Nanomaterials are currently the state-of-the-art in the development of advanced biomedical
devices and applications where classical approaches have failed. To date, majority of the …

Investigation of cell-substrate adhesion properties of living chondrocyte by measuring adhesive shear force and detachment using AFM and inverse FEA

TD Nguyen, YT Gu - Scientific reports, 2016 - nature.com
It is well-known that cell adhesion is important in many biological processes such as cell
migration and proliferation. A better understanding of the cell adhesion process will shed …

Experimental and data analysis workflow for soft matter nanoindentation

G Ciccone, MA Gonzalez Oliva… - Journal of …, 2022 - research-collection.ethz.ch
Nanoindentation refers to a class of experimental techniques where a micrometric force
probe is used to quantify the local mechanical properties of soft biomaterials and cells. This …

Comparison of cell mechanical measurements provided by Atomic Force Microscopy (AFM) and Micropipette Aspiration (MPA)

R Daza, B González-Bermúdez, J Cruces… - Journal of the …, 2019 - Elsevier
A comparative analysis of T-lymphocyte mechanical data obtained from Micropipette
Aspiration (MPA) and Atomic Force Microscopy (AFM) is presented. Results obtained by …

Effect of substrate stiffness on mechanical coupling and force propagation at the infarct boundary

DT Nguyen, N Nagarajan, P Zorlutuna - Biophysical journal, 2018 - cell.com
Heterogeneous intercellular coupling plays a significant role in mechanical and electrical
signal transmission in the heart. Although many studies have investigated the electrical …

Biophysical response of living cells to boron nitride nanoparticles: uptake mechanism and bio-mechanical characterization

MAI Rasel, T Li, TD Nguyen, S Singh, Y Zhou… - Journal of Nanoparticle …, 2015 - Springer
Boron nitride nanomaterials have attracted significant interest due to their superior chemical
and physical properties. Despite these novel properties, investigation on the interaction …

2D vs. 3D Evaluation of Osteocyte Lacunae-Methodological Approaches, Recommended Parameters, and Challenges: A Narrative Review by the European Calcified …

A Vom Scheidt, J Krug, P Goggin, AD Bakker… - Current osteoporosis …, 2024 - Springer
Abstract Purpose of Review Quantification of the morphology of osteocyte lacunae has
become a powerful tool to investigate bone metabolism, pathologies and aging. This review …