CircRNAs: role in human diseases and potential use as biomarkers
L Verduci, E Tarcitano, S Strano, Y Yarden… - Cell death & …, 2021 - nature.com
Circular RNAs (circRNAs) are a class of endogenous RNAs characterized by a covalent
loop structure. In comparison to other types of RNAs, the abundance of circRNAs is relatively …
loop structure. In comparison to other types of RNAs, the abundance of circRNAs is relatively …
The circ RNA–micro RNA code: emerging implications for cancer diagnosis and treatment
L Verduci, S Strano, Y Yarden… - Molecular oncology, 2019 - Wiley Online Library
Circular RNA s (circ RNA s) comprise an emerging new class of endogenous RNA s
expressed abundantly by the eukaryotic transcriptome. They are characterized by a …
expressed abundantly by the eukaryotic transcriptome. They are characterized by a …
The circRNA circAGFG1 acts as a sponge of miR-195-5p to promote triple-negative breast cancer progression through regulating CCNE1 expression
R Yang, L Xing, X Zheng, Y Sun, X Wang, J Chen - Molecular cancer, 2019 - Springer
Background In recent years, circular RNAs (circRNAs), a new star of non-coding RNA, have
been emerged as vital regulators and gained much attention for involvement of initiation and …
been emerged as vital regulators and gained much attention for involvement of initiation and …
Insulin receptor isoforms in physiology and disease: an updated view
A Belfiore, R Malaguarnera, V Vella… - Endocrine …, 2017 - academic.oup.com
The insulin receptor (IR) gene undergoes differential splicing that generates two IR isoforms,
IR-A and IR-B. The physiological roles of IR isoforms are incompletely understood and …
IR-A and IR-B. The physiological roles of IR isoforms are incompletely understood and …
Portrait of the PI3K/AKT pathway in colorectal cancer
SA Danielsen, PW Eide, A Nesbakken, T Guren… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Abstract PI3K/AKT signaling leads to reduced apoptosis, stimulates cell growth and
increases proliferation. Under normal conditions, PI3K/AKT activation is tightly controlled …
increases proliferation. Under normal conditions, PI3K/AKT activation is tightly controlled …
A graph auto-encoder model for miRNA-disease associations prediction
Emerging evidence indicates that the abnormal expression of miRNAs involves in the
evolution and progression of various human complex diseases. Identifying disease-related …
evolution and progression of various human complex diseases. Identifying disease-related …
Non-coding RNAs in breast cancer: intracellular and intercellular communication
CM Klinge - Non-coding RNA, 2018 - mdpi.com
Non-coding RNAs (ncRNAs) are regulators of intracellular and intercellular signaling in
breast cancer. ncRNAs modulate intracellular signaling to control diverse cellular processes …
breast cancer. ncRNAs modulate intracellular signaling to control diverse cellular processes …
The oncogenic role of circPVT1 in head and neck squamous cell carcinoma is mediated through the mutant p53/YAP/TEAD transcription-competent complex
L Verduci, M Ferraiuolo, A Sacconi, F Ganci, J Vitale… - Genome biology, 2017 - Springer
Abstract Background Circular RNAs are a class of endogenous RNAs with various functions
in eukaryotic cells. Worthy of note, circular RNAs play a critical role in cancer. Currently …
in eukaryotic cells. Worthy of note, circular RNAs play a critical role in cancer. Currently …
Identification of circulating microRNA signatures for breast cancer detection
M Chan, CS Liaw, SM Ji, HH Tan, CY Wong… - Clinical cancer …, 2013 - AACR
Purpose: There is a quest for novel noninvasive diagnostic markers for the detection of
breast cancer. The goal of this study is to identify circulating microRNA (miRNA) signatures …
breast cancer. The goal of this study is to identify circulating microRNA (miRNA) signatures …
Epigenetics and microRNAs in cancer
A Ramassone, S Pagotto, A Veronese… - International journal of …, 2018 - mdpi.com
The ability to reprogram the transcriptional circuitry by remodeling the three-dimensional
structure of the genome is exploited by cancer cells to promote tumorigenesis. This …
structure of the genome is exploited by cancer cells to promote tumorigenesis. This …