Therapeutically harnessing extracellular vesicles

L Cheng, AF Hill - Nature Reviews Drug Discovery, 2022 - nature.com
The field of extracellular vesicle (EV) research has developed rapidly over the last decade
from the study of fundamental biology to a subject of significant clinical relevance. The …

Recent advances in exosome-mediated nucleic acid delivery for cancer therapy

Y Zhang, Q Liu, X Zhang, H Huang, S Tang… - Journal of …, 2022 - Springer
Cancer is a leading public health problem worldwide. Its treatment remains a daunting
challenge, although significant progress has been made in existing treatments in recent …

Therapeutic roles of mesenchymal stem cell-derived extracellular vesicles in cancer

Z Weng, B Zhang, C Wu, F Yu, B Han, B Li… - Journal of hematology & …, 2021 - Springer
Extracellular vesicles (EVs) are cell-derived membrane structures enclosing proteins, lipids,
RNAs, metabolites, growth factors, and cytokines. EVs have emerged as essential …

[HTML][HTML] Exosomes, a new star for targeted delivery

H Chen, L Wang, X Zeng, H Schwarz… - Frontiers in cell and …, 2021 - frontiersin.org
Exosomes are cell-secreted nanoparticles (generally with a size of 30-150 nm) bearing
numerous biological molecules including nucleic acids, proteins and lipids, which are …

Challenges in the development and establishment of exosome-based drug delivery systems

J Wang, D Chen, EA Ho - Journal of Controlled Release, 2021 - Elsevier
Exosomes are extracellular vesicles released from cells and are characterized by a lipid
bilayer membrane encapsulating a variety of biological molecules such as nucleic acids or …

Exosomes and exosome-inspired vesicles for targeted drug delivery

SG Antimisiaris, S Mourtas, A Marazioti - Pharmaceutics, 2018 - mdpi.com
The similarities between exosomes and liposomes, together with the high organotropism of
several types of exosomes, have recently prompted the development of engineered …

Engineering exosomes as refined biological nanoplatforms for drug delivery

X Luan, K Sansanaphongpricha, I Myers… - Acta Pharmacologica …, 2017 - nature.com
Exosomes, a subgroup of extracellular vesicles (EVs), have been recognized as important
mediators of long distance intercellular communication and are involved in a diverse range …

Potential use of exosomes as diagnostic biomarkers and in targeted drug delivery: progress in clinical and preclinical applications

MN Huda, M Nafiujjaman, IG Deaguero… - ACS biomaterials …, 2021 - ACS Publications
Exosomes are cell-derived vesicles containing heterogeneous active biomolecules such as
proteins, lipids, mRNAs, receptors, immune regulatory molecules, and nucleic acids. They …

Towards microfluidic-based exosome isolation and detection for tumor therapy

J Wang, P Ma, DH Kim, BF Liu, U Demirci - Nano Today, 2021 - Elsevier
Exosomes are a class of cell-secreted, nano-sized extracellular vesicles with a bilayer
membrane structure of 30–150 nm in diameter. Their discovery and application have …

Exosome engineering in cell therapy and drug delivery

S Sadeghi, FR Tehrani, S Tahmasebi, A Shafiee… - …, 2023 - Springer
Cell-derived exosomes have opened new horizons in modern therapy for advanced drug
delivery and therapeutic applications, due to their key features such as low immunogenicity …