SLC6 neurotransmitter transporters: structure, function, and regulation
AS Kristensen, J Andersen, TN Jørgensen… - Pharmacological …, 2011 - ASPET
The neurotransmitter transporters (NTTs) belonging to the solute carrier 6 (SLC6) gene
family (also referred to as the neurotransmitter-sodium-symporter family or Na+/Cl …
family (also referred to as the neurotransmitter-sodium-symporter family or Na+/Cl …
SLC6 transporters: structure, function, regulation, disease association and therapeutics
The SLC6 family of secondary active transporters are integral membrane solute carrier
proteins characterized by the Na+-dependent translocation of small amino acid or amino …
proteins characterized by the Na+-dependent translocation of small amino acid or amino …
Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut
The gut microbiota regulates levels of serotonin (5-hydroxytryptamine (5-HT)) in the
intestinal epithelium and lumen,,,–. However, whether 5-HT plays a functional role in …
intestinal epithelium and lumen,,,–. However, whether 5-HT plays a functional role in …
X-ray structures and mechanism of the human serotonin transporter
The serotonin transporter (SERT) terminates serotonergic signalling through the sodium-and
chloride-dependent reuptake of neurotransmitter into presynaptic neurons. SERT is a target …
chloride-dependent reuptake of neurotransmitter into presynaptic neurons. SERT is a target …
X-ray structure of dopamine transporter elucidates antidepressant mechanism
A Penmatsa, KH Wang, E Gouaux - Nature, 2013 - nature.com
Abstract Antidepressants targeting Na+/Cl−-coupled neurotransmitter uptake define a key
therapeutic strategy to treat clinical depression and neuropathic pain. However, identifying …
therapeutic strategy to treat clinical depression and neuropathic pain. However, identifying …
Molecular basis for substrate recognition and transport of human GABA transporter GAT1
A Zhu, J Huang, F Kong, J Tan, J Lei, Y Yuan… - Nature Structural & …, 2023 - nature.com
Abstract γ-Aminobutyric acid (GABA), an important inhibitory neurotransmitter in the central
nervous system, is recycled through specific GABA transporters (GATs). GAT1, which is …
nervous system, is recycled through specific GABA transporters (GATs). GAT1, which is …
[HTML][HTML] The structural basis of secondary active transport mechanisms
LR Forrest, R Krämer, C Ziegler - Biochimica et Biophysica Acta (BBA) …, 2011 - Elsevier
Secondary active transporters couple the free energy of the electrochemical potential of one
solute to the transmembrane movement of another. As a basic mechanistic explanation for …
solute to the transmembrane movement of another. As a basic mechanistic explanation for …
[图书][B] Introduction to proteins: structure, function, and motion
Introduction to Proteins provides a comprehensive and state-of-the-art introduction to the
structure, function, and motion of proteins for students, faculty, and researchers at all levels …
structure, function, and motion of proteins for students, faculty, and researchers at all levels …
The solute carrier 6 family of transporters
The solute carrier 6 (SLC6) family of the human genome comprises transporters for
neurotransmitters, amino acids, osmolytes and energy metabolites. Members of this family …
neurotransmitters, amino acids, osmolytes and energy metabolites. Members of this family …
The mechanism of a neurotransmitter: sodium symporter—inward release of Na+ and substrate is triggered by substrate in a second binding site
Eukaryotic neurotransmitter: sodium symporters (NSSs), targets for antidepressants and
psychostimulants, terminate neurotransmission by sodium-driven reuptake. The crystal …
psychostimulants, terminate neurotransmission by sodium-driven reuptake. The crystal …