Reviewing the genetics of heterogeneity in depression: operationalizations, manifestations and etiologies
With progress in genome-wide association studies of depression, from identifying zero hits
in~ 16 000 individuals in 2013 to 223 hits in more than a million individuals in 2020 …
in~ 16 000 individuals in 2013 to 223 hits in more than a million individuals in 2020 …
Polygenic risk scores derived from varying definitions of depression and risk of depression
Importance Genetic studies with broad definitions of depression may not capture genetic risk
specific to major depressive disorder (MDD), raising questions about how depression …
specific to major depressive disorder (MDD), raising questions about how depression …
Genome-by-trauma exposure interactions in adults with depression in the UK biobank
Importance Self-reported trauma exposure has consistently been found to be a risk factor for
major depressive disorder (MDD), and several studies have reported interactions with …
major depressive disorder (MDD), and several studies have reported interactions with …
[HTML][HTML] Factors associated with anxiety disorder comorbidity
MR Davies, K Glen, J Mundy, AR Ter Kuile… - Journal of Affective …, 2023 - Elsevier
Background Anxiety and depressive disorders often co-occur and the order of their
emergence may be associated with different clinical outcomes. However, minimal research …
emergence may be associated with different clinical outcomes. However, minimal research …
The associations among childhood trauma, loneliness, mental health symptoms, and indicators of social exclusion in adulthood: A UK Biobank study
Aims Childhood trauma has been associated with adult psychosocial outcomes linked to
social exclusion. However, the strength of these associations in the general population is …
social exclusion. However, the strength of these associations in the general population is …
Identification of shared disease marker genes and underlying mechanisms between major depression and rheumatoid arthritis
M Dmitrzak-Węglarz, J Rybakowski… - Journal of psychiatric …, 2023 - Elsevier
Both depression and rheumatoid arthritis (RA) have a very high comorbidity rate. A bilateral
association is estimated to increase the mutual risk and the common denominator is …
association is estimated to increase the mutual risk and the common denominator is …
The association between trauma exposure, polygenic risk and individual depression symptoms
Background Traumatic experiences are associated with increased risk for major depressive
disorder (MDD). This study sought to determine the extent that trauma exposure, depression …
disorder (MDD). This study sought to determine the extent that trauma exposure, depression …
A person‐centered data analytic approach to dopaminergic polygenic moderation of child maltreatment exposure
The present study illustrates the utility of latent class analysis, a person‐centered data
analytic approach, as an innovative method for identifying naturally occurring patterns of …
analytic approach, as an innovative method for identifying naturally occurring patterns of …
Using Alternative Definitions of Controls to Increase Statistical Power in GWAS
Genome-wide association studies (GWAS) are often underpowered due to small effect sizes
of common single nucleotide polymorphisms (SNPs) on phenotypes and extreme multiple …
of common single nucleotide polymorphisms (SNPs) on phenotypes and extreme multiple …
Exploring polygenic‐environment and residual‐environment interactions for depressive symptoms within the UK Biobank
Substantial advances have been made in identifying genetic contributions to depression, but
little is known about how the effect of genes can be modulated by the environment, creating …
little is known about how the effect of genes can be modulated by the environment, creating …