During the past decade there has been a substantial advance in our understanding of
estrogen signaling both from a clinical as well as a preclinical perspective. Estrogen …

Breast cancer is a heterogeneous disease that encompasses several distinct entities with
remarkably different biological characteristics and clinical behaviour. Currently, breast …

The epithelial–mesenchymal transition (EMT) describes a rapid and often reversible
modulation of phenotype by epithelial cells. EMT was originally defined in the context of …

Histologic grading of breast cancer defines morphologic subtypes informative of metastatic
potential, although not without considerable interobserver disagreement and clinical …

Lopez‐Garcia MA, Geyer FC, Lacroix‐Triki M, Marchió C & Reis‐Filho JS (2010)
Histopathology 57, 171–192 Breast cancer precursors revisited: molecular features and …

p53 plays a key role in mediating cell response to various stresses, mainly by inducing or
repressing a number of genes involved in cell cycle arrest, senescence, apoptosis, DNA …

Abstract Analysis of gene expression data suggests that breast cancers are divisible into
molecular subtypes which have distinct clinical features. This study evaluates whether …

Breast cancers arising in germline carriers of BRCA1 mutations have a characteristic
phenotype that has been shown in many studies to differentiate BRCA1 tumours from …

Background We analysed the clinical features, distribution of basal markers, prevalence of
oncogene amplification, and outcome of triple negative (TN) compared to those of non-TN …

The development of distant metastases is the major cause of death from breast cancer. In
order to predict and prevent tumour spreading, many attempts are being made to detect …