Levodopa therapy for Parkinson's disease: pharmacokinetics and pharmacodynamics

PA LeWitt - Movement Disorders, 2015 - Wiley Online Library
For all its imperfections at treating Parkinson's disease (PD), orally‐administered levodopa (l‐
dopa) can be regarded as the “platinum” standard of PD therapeutics for its impact on …

The therapeutic role of ketogenic diet in neurological disorders

D Pietrzak, K Kasperek, P Rękawek… - Nutrients, 2022 - mdpi.com
The ketogenic diet (KD) is a high-fat, low-carbohydrate and adequate-protein diet that has
gained popularity in recent years in the context of neurological diseases (NDs). The …

Endocannabinoid system in neurodegenerative disorders

BS Basavarajappa, M Shivakumar… - Journal of …, 2017 - Wiley Online Library
Most neurodegenerative disorders (NDD s) are characterized by cognitive impairment and
other neurological defects. The definite cause of and pathways underlying the progression …

From Cannabis sativa to Cannabidiol: Promising Therapeutic Candidate for the Treatment of Neurodegenerative Diseases

T Cassano, R Villani, L Pace, A Carbone… - Frontiers in …, 2020 - frontiersin.org
Cannabis sativa, commonly known as marijuana, contains a pool of secondary plant
metabolites with therapeutic effects. Besides Δ9-tetrahydrocannabinol that is the principal …

Cannabinoid receptor 2 signaling in neurodegenerative disorders: from pathogenesis to a promising therapeutic target

T Cassano, S Calcagnini, L Pace, F De Marco… - Frontiers in …, 2017 - frontiersin.org
As a consequence of an increasingly aging population, the number of people affected by
neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease and …

Mitochondrial complex I as a pathologic and therapeutic target for Parkinson's disease

KP Tryphena, US Nikhil, P Pinjala… - ACS Chemical …, 2023 - ACS Publications
The prevalence of Parkinson's disease (PD) continues to increase despite substantial
research. Mounting evidence states that dysfunctional mitochondrial bioenergetics play a …

The relationships of vitamin D, vitamin D receptor gene polymorphisms, and vitamin D supplementation with Parkinson's disease

L Lv, X Tan, X Peng, R Bai, Q Xiao, T Zou, J Tan… - Translational …, 2020 - Springer
In recent years, many studies have investigated the correlations between Parkinson's
disease (PD) and vitamin D status, but the conclusion remains elusive. The present review …

The protein disulfide isomerase family: from proteostasis to pathogenesis

M Matsusaki, S Kanemura, M Kinoshita, YH Lee… - … et Biophysica Acta (BBA …, 2020 - Elsevier
In mammalian cells, nearly one-third of proteins are inserted into the endoplasmic reticulum
(ER), where they undergo oxidative folding and chaperoning assisted by approximately 20 …

Ketone bodies and brain metabolism: new insights and perspectives for neurological diseases

W López-Ojeda, RA Hurley - The Journal of Neuropsychiatry …, 2023 - Am Neuropsych Assoc
FIGURE 1. Ketogenesis (simplified). A. When systemic blood glucose levels drop, the low
endogenous carbohydrate levels are unable to sustain the energy requirements of the body …

The role of ketogenic diet in the treatment of neurological diseases

D Dyńka, K Kowalcze, A Paziewska - Nutrients, 2022 - mdpi.com
Over a hundred years of study on the favourable effect of ketogenic diets in the treatment of
epilepsy have contributed to a long-lasting discussion on its potential influence on other …