During embryogenesis tissue layers undergo morphogenetic flow rearranging and folding
into specific shapes. While developmental biology has identified key genes and local …

Organ architecture is often composed of multiple laminar tissues arranged in concentric
layers. During morphogenesis, the initial geometry of visceral organs undergoes a …

Anaplastic lymphoma kinase (Alk) is an evolutionary conserved receptor tyrosine kinase
belonging to the insulin receptor superfamily. In addition to its well-studied role in cancer …

Plants deploy versatile scaffold proteins to intricately modulate complex cell signaling.
Among these, RACK1A (Receptors for Activated C Kinase 1A) stands out as a multifaceted …

Activating anaplastic lymphoma kinase (ALK) receptor tyrosine kinase (RTK) mutations
occur in pediatric neuroblastoma and are associated with poor prognosis. To study ALK …

Neuroblastoma is a neural crest-derived paediatric cancer that is the most common and
deadly solid extracranial tumour of childhood. It arises when neural crest cells fail to follow …

Comparative genomic analyses have enormous potential for identifying key genes central to
human health phenotypes, including those that promote cancers. In particular, the …

Numerous roles for the Alk receptor tyrosine kinase have been described in Drosophila,
including functions in the CNS, however the molecular details are poorly understood. To …

Numerous roles for the Alk receptor tyrosine kinase have been described in Drosophila,
including functions in the central nervous system (CNS), however the molecular details are …

Development of the Drosophila visceral muscle depends on Anaplastic Lymphoma Kinase
(Alk) receptor tyrosine kinase (RTK) signaling, which specifies founder cells (FCs) in the …