Neuromelanin-sensitive MRI for mechanistic research and biomarker development in psychiatry

K Wengler, P Trujillo, CM Cassidy… - …, 2024 - nature.com
Neuromelanin-sensitive MRI is a burgeoning non-invasive neuroimaging method with an
increasing number of applications in psychiatric research. This MRI modality is sensitive to …

Generalizability and out-of-sample predictive ability of associations between neuromelanin-sensitive magnetic resonance imaging and psychosis in antipsychotic-free …

K Wengler, SC Baker, A Velikovskaya… - JAMA …, 2024 - jamanetwork.com
Importance The link between psychosis and dopaminergic dysfunction is established, but no
generalizable biomarkers with clear potential for clinical adoption exist. Objective To …

Neurobiology of Obsessive–Compulsive Disorder from Genes to Circuits: Insights from Animal Models

YD Zhang, DD Shi, Z Wang - Neuroscience Bulletin, 2024 - Springer
Obsessive-compulsive disorder (OCD) is a chronic, severe psychiatric disorder that has
been ranked by the World Health Organization as one of the leading causes of illness …

Forebrain EAAT3 overexpression increases susceptibility to amphetamine-induced repetitive behaviors

JM Kopelman, MO Chohan, AI Hsu, EA Yttri… - Eneuro, 2024 - eneuro.org
Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder characterized by
intrusive obsessive thoughts and compulsive behaviors. Multiple studies have shown the …

Neuromelanin-sensitive magnetic resonance imaging in the study of mental disorder: A systematic review

Q Lv, X Wang, P Lin, X Wang - Psychiatry Research: Neuroimaging, 2024 - Elsevier
Dopamine and norepinephrine are implicated in the pathophysiology of mental disorders,
but non-invasive study of their neuronal function remains challenging. Recent research …

Assessing midbrain neuromelanin and its relationship to reward learning in anorexia nervosa: Stage 1 of a registered report

SB Murray, JP Diaz‐Fong, VWT Mak… - Brain and …, 2024 - Wiley Online Library
Introduction Anorexia nervosa (AN) is a debilitating and potentially chronic eating disorder,
characterized by low hedonic drive toward food, which has been linked with perturbations in …

[PDF][PDF] Child & Adolescent Psychiatry Grand Rounds

KD Fitzgerald - psychiatry.weill.cornell.edu
Early intervention with cognitive behavioral therapy is recommended for pediatric OCD and
anxiety disorders, but young patients often remain symptomatic even after treatment. To …