Background Liver is a vital organ responsible for metabolizing and detoxifying both
endogenous and exogenous substances in the body. However, it is susceptible to damage …

Citrus fruits are grown worldwide for their special nutritive and several health benefits.
Among citrus bioactives, naringenin, a major flavanone, exhibits a potential hepatoprotective …

Significance: Ample evidence has demonstrated an important role for autophagy as either a
protective mechanism or a cause for hepatotoxicity, denoting the likely potentials for …

Acute liver failure (ALF) is considered a fatal clinical disorder and novel therapeutic
interventions are mandatory. Naringenin is a flavonoid with anti-inflammatory, antioxidant …

Autophagy is a pivotal contributing factor to modulate the progression of neurodegenerative
diseases. Although naringenin (Nar) has shown beneficial effects against …

The renin-angiotensin system (RAS) has been recognized as a crucial contributor to the
development of liver fibrosis, and AT2R, an essential component of RAS, is involved in the …

Abstract Background Pilea umbrosa (Urticaceae) is used by local communities (district
Abbotabad) for liver disorders, as anticancer, in rheumatism and in skin disorders. Methods …

肝纤维化是各种因素导致的胶原大量沉积和炎症过度反应的病理过程, 严重威胁人类的健康.
寻求有效的肝纤维化治疗策略是全球性的医学难题. 内质网损伤导致内质网应激 …

Liver fibrosis has a high incidence worldwide and is the common pathological basis of many
chronic liver diseases. Liver fibrosis is caused by the excessive deposition of extracellular …

错误/未折叠蛋白的积累可导致内质网(endoplasmic reticulum, ER) 结构和功能紊乱,
从而诱发内质网应激(endoplasmic reticulum stress, ERS), 激活未折叠蛋白反应(unfolded …