Membrane attack by complement: the assembly and biology of terminal complement complexes
CA Tegla, C Cudrici, S Patel, R Trippe, V Rus… - Immunologic …, 2011 - Springer
Complement system activation plays an important role in both innate and acquired immunity.
Activation of the complement and the subsequent formation of C5b-9 channels (the …
Activation of the complement and the subsequent formation of C5b-9 channels (the …
[HTML][HTML] Complement in atherosclerosis: friend or foe?
Atherosclerosis is a chronic inflammatory disease and the complement system plays a
central role in innate immunity. Increasing evidence exists that the complement system is …
central role in innate immunity. Increasing evidence exists that the complement system is …
COVID, complement, and the brain
The brains of COVID-19 patients are affected by the SARS-CoV-2 virus, and these effects
may contribute to several COVID-19 sequelae, including cognitive dysfunction (termed “long …
may contribute to several COVID-19 sequelae, including cognitive dysfunction (termed “long …
The role of complement system in adipose tissue-related inflammation
As the common factor linking adipose tissue to the metabolic context of obesity, insulin
resistance and atherosclerosis are associated with a low-grade chronic inflammatory status …
resistance and atherosclerosis are associated with a low-grade chronic inflammatory status …
The complement system as a biomarker of disease activity and response to treatment in multiple sclerosis
A Tatomir, A Talpos-Caia, F Anselmo… - Immunologic …, 2017 - Springer
Multiple sclerosis (MS) is an inflammatory, demyelinating, and neurodegenerative disease
of the central nervous system. The complement system has an established role in the …
of the central nervous system. The complement system has an established role in the …
Complement links platelets to innate immunity
H Nording, HF Langer - Seminars in immunology, 2018 - Elsevier
The complement system is a versatile part of our immune system. Various intersection points
of complement with other cells and molecules of the immune response are well described …
of complement with other cells and molecules of the immune response are well described …
Sub-lytic C5b-9 induces functional changes in retinal pigment epithelial cells consistent with age-related macular degeneration
K Lueck, S Wasmuth, J Williams, TR Hughes… - Eye, 2011 - nature.com
Purpose There is evidence for complement dysfunction in age-related macular degeneration
(AMD). Complement activation leads to formation of the membrane attack complex (MAC) …
(AMD). Complement activation leads to formation of the membrane attack complex (MAC) …
The role of complement activation in atherogenesis: the first 40 years
The pathogenesis of atherosclerotic inflammation is a multi-step process defined by the
interweaving of excess modified lipid particles, monocyte-macrophages populations, and …
interweaving of excess modified lipid particles, monocyte-macrophages populations, and …
Response gene to complement 32 (RGC-32) expression on M2-polarized and tumor-associated macrophages is M-CSF-dependent and enhanced by tumor-derived …
P Zhao, D Gao, Q Wang, B Song, Q Shao… - Cellular & molecular …, 2015 - nature.com
Response gene to complement 32 (RGC-32) is a cell cycle regulator involved in the
proliferation, differentiation and migration of cells and has also been implicated in …
proliferation, differentiation and migration of cells and has also been implicated in …
RGC-32 (response gene to complement 32) deficiency protects endothelial cells from inflammation and attenuates atherosclerosis
Objective—The objective of this study is to determine the role and underlying mechanisms of
RGC-32 (response gene to complement 32 protein) in atherogenesis. Approach and Results …
RGC-32 (response gene to complement 32 protein) in atherogenesis. Approach and Results …