[HTML][HTML] Sphingosine 1-phosphate (S1P)/S1P receptor signaling and mechanotransduction: implications for intrinsic tissue repair/regeneration

C Sassoli, F Pierucci, S Zecchi-Orlandini… - International journal of …, 2019 - mdpi.com
Tissue damage, irrespective from the underlying etiology, destroys tissue structure and,
eventually, function. In attempt to achieve a morpho-functional recover of the damaged …

Adaptive exhaustion during prolonged intermittent hypoxia causes dysregulated skeletal muscle protein homeostasis

AH Attaway, A Bellar, S Mishra… - The Journal of …, 2023 - Wiley Online Library
Nocturnal hypoxaemia, which is common in chronic obstructive pulmonary disease (COPD)
patients, is associated with skeletal muscle loss or sarcopenia, which contributes to adverse …

[HTML][HTML] Biomaterials-induced stem cells specific differentiation into intervertebral disc lineage cells

Y Peng, D Huang, S Liu, J Li, X Qing… - … in Bioengineering and …, 2020 - frontiersin.org
Stem cell therapy, which promotes stem cells differentiation toward specialized cell types,
increases the resident population and production of extracellular matrix, and can be used to …

Remote ischemic conditioning reduced acute lung injury after traumatic brain injury in the mouse

M Saber, AD Rice, I Christie, RG Roberts, KS Knox… - Shock, 2021 - journals.lww.com
Traumatic brain injury (TBI) can induce acute lung injury (ALI). The exact pathomechanism
of TBI-induced ALI is poorly understood, limiting treatment options. Remote ischemic …

[HTML][HTML] The protein kinase Cmk2 negatively regulates the calcium/calcineurin signalling pathway and expression of calcium pump genes PMR1 and PMC1 in …

H Xu, T Fang, H Yan, L Jiang - Cell Communication and Signaling, 2019 - Springer
Through a genome-wide screen we have identified calcium-tolerant deletion mutants for five
genes in the budding yeast Saccharomyces cerevisiae. In addition to CNB1 and RCN1 that …

[HTML][HTML] Regulation of serum sphingolipids in Andean children born and living at high altitude (3775 m)

P Barbacini, J Casas, E Torretta, D Capitanio… - International journal of …, 2019 - mdpi.com
Recent studies on Andean children indicate a prevalence of dyslipidemia and hypertension
compared to dwellers at lower altitudes, suggesting that despite similar food intake and daily …

Preventive preclinical efficacy of intravenously administered sphingosine-1-phosphate (S1P) in strengthening hypoxia adaptive responses to acute and sub-chronic …

S Chawla, B Rahar, R Tulswani, S Saxena - European Journal of …, 2020 - Elsevier
Abstract Sphingosine-1-phosphate (S1P) is emerging as a hypoxia responsive bio-lipid;
systemically raised levels of S1P are proposed to have potential hypoxia pre-conditioning …

Sphingosine 1-phosphate in sepsis and beyond: its role in disease tolerance and host defense and the impact of carrier molecules

AC Ziegler, T Müller, MH Gräler - Cellular Signalling, 2021 - Elsevier
Abstract Sphingosine 1-phosphate (S1P) is an important immune modulator responsible for
physiological cellular responses like lymphocyte development and function, positioning and …

Hypoxia transactivates cholecystokinin gene expression in 3D-engineered muscle

T Nakamura, S Takagi, D Okuzaki, S Matsui… - Journal of bioscience …, 2021 - Elsevier
Highlights•Acute electrical pulse stimulation (EPS) induced cholecystokinin CCK
signaling.•Cck was constitutively upregulated in 3D-engineered muscle.•Cck expression …

A Nanocurcumin and Pyrroloquinoline Quinone Formulation Prevents Hypobaric Hypoxia-Induced Skeletal Muscle Atrophy by Modulating NF-κB Signaling Pathway

AD Kushwaha, D Saraswat - High Altitude Medicine & Biology, 2022 - liebertpub.com
Kushwaha, Asha D., and Deepika Saraswat. A nanocurcumin and pyrroloquinoline quinone
formulation prevents hypobaric hypoxia-induced skeletal muscle atrophy by modulating NF …