Designing spatial and temporal control of vaccine responses
Vaccines are the key technology to combat existing and emerging infectious diseases.
However, increasing the potency, quality and durability of the vaccine response remains a …
However, increasing the potency, quality and durability of the vaccine response remains a …
The link between circulating follicular helper T cells and autoimmunity
LSK Walker - Nature Reviews Immunology, 2022 - nature.com
Follicular helper T (TFH) cells provide help to B cells, supporting the formation of germinal
centres that allow affinity maturation of antibody responses. Although usually located in …
centres that allow affinity maturation of antibody responses. Although usually located in …
Antigen presentation by dendritic cells and their instruction of CD4+ T helper cell responses
KL Hilligan, F Ronchese - Cellular & molecular immunology, 2020 - nature.com
Dendritic cells are powerful antigen-presenting cells that are essential for the priming of T
cell responses. In addition to providing T-cell-receptor ligands and co-stimulatory molecules …
cell responses. In addition to providing T-cell-receptor ligands and co-stimulatory molecules …
B cells and T follicular helper cells mediate response to checkpoint inhibitors in high mutation burden mouse models of breast cancer
This study identifies mechanisms mediating responses to immune checkpoint inhibitors
using mouse models of triple-negative breast cancer. By creating new mammary tumor …
using mouse models of triple-negative breast cancer. By creating new mammary tumor …
The γc family of cytokines: basic biology to therapeutic ramifications
WJ Leonard, JX Lin, JJ O'Shea - Immunity, 2019 - cell.com
The common cytokine receptor γ chain, γ c, is a component of the receptors for interleukin-2
(IL-2), IL-4, IL-7, IL-9, IL-15, and IL-21. Mutation of the gene encoding γ c results in X-linked …
(IL-2), IL-4, IL-7, IL-9, IL-15, and IL-21. Mutation of the gene encoding γ c results in X-linked …
Interleukin-21, acting beyond the immunological synapse, independently controls T follicular helper and germinal center B cells
Germinal centers (GCs), transient structures within B cell follicles and central to affinity
maturation, require the coordinated behavior of T and B cells. IL-21, a pleiotropic T cell …
maturation, require the coordinated behavior of T and B cells. IL-21, a pleiotropic T cell …
Spike-specific circulating T follicular helper cell and cross-neutralizing antibody responses in COVID-19-convalescent individuals
J Zhang, Q Wu, Z Liu, Q Wang, J Wu, Y Hu, T Bai… - Nature …, 2021 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) is caused by infection with severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2),–and individuals with COVID-19 have …
respiratory syndrome coronavirus 2 (SARS-CoV-2),–and individuals with COVID-19 have …
CD4+T Cells: Differentiation and Functions
RV Luckheeram, R Zhou, AD Verma… - Journal of Immunology …, 2012 - Wiley Online Library
CD4+ T cells are crucial in achieving a regulated effective immune response to pathogens.
Naive CD4+ T cells are activated after interaction with antigen‐MHC complex and …
Naive CD4+ T cells are activated after interaction with antigen‐MHC complex and …
The role of interleukin-2 during homeostasis and activation of the immune system
Abstract Interleukin-2 (IL-2) signals influence various lymphocyte subsets during
differentiation, immune responses and homeostasis. As discussed in this Review …
differentiation, immune responses and homeostasis. As discussed in this Review …
Tertiary lymphoid structures, drivers of the anti‐tumor responses in human cancers
MC Dieu‐Nosjean, NA Giraldo, H Kaplon… - Immunological …, 2016 - Wiley Online Library
The characterization of the microenvironment of human tumors led to the description of
tertiary lymphoid structures (TLS) characterized by mature dendritic cells in a T‐cell zone …
tertiary lymphoid structures (TLS) characterized by mature dendritic cells in a T‐cell zone …