The diverse leukocyte infiltrate in atherosclerotic mouse aortas was recently analyzed in 9
single-cell RNA sequencing and 2 mass cytometry studies. In a comprehensive meta …

Pathological vascular wall remodeling refers to the structural and functional changes of the
vessel wall that occur in response to injury that eventually leads to cardiovascular disease …

Emerging evidence indicates that angiogenesis and immunosuppression frequently occur
simultaneously in response to diverse stimuli. Here, we describe a fundamental biological …

Atherosclerosis and aortic valve sclerosis are cardiovascular diseases with an increasing
prevalence in western societies. Statins are widely applied in atherosclerosis therapy …

Natural killer T (NKT) cells are important regulatory lymphocytes that have been shown in
mouse studies, to have a crucial role in promoting immunity to tumours, bacteria and viruses …

In spite of their precipitous encounter with the environment, newborn infants cannot readily
mount T helper type 1 (TH1) cell antibacterial and antiviral responses. Instead, they show …

The development and maturation of semi-invariant natural killer T cells (i NKT cells) rely on
the recognition of self antigens presented by CD1d restriction molecules in thymus. The …

CD1-and MHC-related molecule-1 (MR1)-restricted T lymphocytes recognize nonpeptidic
antigens, such as lipids and small metabolites, and account for a major fraction of circulating …

Aims Myocardial infarction (MI) accelerates atherosclerosis and greatly increases the risk of
recurrent cardiovascular events for many years, in particular, strokes and MIs. Because B …

Atherosclerosis is a chronic inflammatory disorder that develops in response to
hyperlipidaemia. Cells from both the innate and adaptive immune systems contribute to the …