Eukaryotic cells compartmentalize their internal milieu in order to achieve specific reactions
in time and space. This organization in distinct compartments is essential to allow …

The functional organization of eukaryotic DNA into chromatin uses histones as components
of its building block, the nucleosome. Histone chaperones, which are proteins that escort …

Identification of host genes essential for severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection may reveal novel therapeutic targets and inform our understanding …

Establishment of a proper chromatin landscape is central to genome function. Here, we
explain H3 variant distribution by specific targeting and dynamics of deposition involving the …

Hsp70s comprise a deeply conserved chaperone family that has a central role in
maintaining protein homeostasis. In humans, Hsp70 client specificity is provided by 49 …

Cellular senescence is a stable proliferation arrest that suppresses tumorigenesis. Cellular
senescence and associated tumor suppression depend on control of chromatin. Histone …

The tumor suppressor gene ATRX is frequently mutated in a variety of tumors including
gliomas and liver cancers, which are highly unresponsive to current therapies. Here, we …

Nucleosomes represent a challenge in regard to transcription. Histone eviction enables
RNA polymerase II (RNAPII) progression through DNA, but compromises chromatin integrity …

Histone chaperones bind specific histones to mediate their storage, eviction or deposition
from/or into chromatin. The HIRA histone chaperone complex, composed of HIRA …

Identification of host genes essential for SARS-CoV-2 infection may reveal novel therapeutic
targets and inform our understanding of COVID-19 pathogenesis. Here we performed a …