Liver sinusoidal endothelial cells (LSECs) line the low shear, sinusoidal capillary channels
of the liver and are the most abundant non-parenchymal hepatic cell population. LSECs do …

The liver is an essential organ that is critical for the removal of toxins, the production of
proteins, and the maintenance of metabolic homeostasis. Behind each liver functional unit …

Infiltration of regulatory T (Treg) cells, an immunosuppressive population of CD4+ T cells,
into solid cancers represents a barrier to cancer immunotherapy. Chemokine receptors are …

Sustained hepatic inflammation is an important factor in progression of chronic liver
diseases, including hepatitis C or non-alcoholic steatohepatitis. Liver inflammation is …

The crucial roles of oxidative stress and inflammation in the development of hepatic
diseases have been unraveled and emphasized for decades. From steatosis to fibrosis …

CXCR3 is a chemokine receptor that is highly expressed on effector T cells and plays an
important role in T cell trafficking and function. CXCR3 is rapidly induced on naïve cells …

The demands that are imposed on the liver as a result of its function as a metabolic organ
that extracts nutrients and clears gut-derived microbial products from the blood are met by a …

Abstract Forkhead box P3 (FOXP3)+ regulatory T (TReg) cells prevent autoimmune disease,
maintain immune homeostasis and modulate immune responses during infection. To …

Regulatory T cells (Tregs) are central to the maintenance of self-tolerance and tissue
homeostasis. Markers commonly used to define human Tregs in the research setting include …

Primary biliary cirrhosis (PBC) is an autoimmune disease characterized by clinical
homogeneity among patients, an overwhelming female predominance, production of a …