Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …

Obesity represents the single most important risk factor for early disability and death in
developed societies, and the incidence of obesity remains at staggering levels. CNS …

The initial discovery that ob/ob mice become obese because of a recessive mutation of the
leptin gene has been crucial to discover the melanocortin pathway to control appetite. In the …

Interactions between the brain and distinct adipose depots have a key role in maintaining
energy balance, thereby promoting survival in response to metabolic challenges such as …

The mouse genetic revolution has shown repeatedly that most organs have more functions
than expected. This has led to the realization that, in addition to a molecular and cellular …

Serotonin has been implicated in the control of satiety for almost four decades. Historically,
the insight that the appetite suppressant effect of fenfluramine is linked to serotonin has …

Over the past 20 years, genetic studies have illuminated critical pathways in the
hypothalamus and brainstem mediating energy homeostasis, such as the melanocortin …

Obesity and diabetes mellitus are great public health concerns throughout the world
because of their increasing incidence and prevalence. Leptin, the adipocyte hormone, is …

The Cre-loxP system is invaluable for spatial and temporal control of gene knockout,
knockin, and reporter expression in the mouse nervous system. However, we report varying …

Leptin is an adipocytokine that circulates in proportion to body fat to signal the repletion of
long-term energy stores. Leptin acts via its receptor, LepRb, on specialized neuronal …