A cure for type 1 diabetes (T1D) would help millions of people worldwide but remains
elusive to date. Tolerogenic vaccines and β-cell replacement therapy are complementary …

Multiple Sclerosis (MS) is a chronic autoimmune disorder affecting the central nervous
system (CNS) through demyelination and neurodegeneration. Until recently, major …

Islet transplantation represents a potentially curative approach for individuals with Type I
Diabetes. The requirement for systemic immune suppression to control immune-mediated …

Regulatory T cells (Tregs) have become highly relevant in the pathophysiology and
treatment of autoimmune diseases, such as type 1 diabetes (T1D). As these cells are known …

Sphingosine 1-phosphate (S1P), derived from membrane sphingolipids, is a pleiotropic
bioactive lipid mediator capable of evoking complex immune phenomena. Studies have …

Abstract Sphingosine-1-phosphate (S1P) can regulate several physiological and
pathological processes. S1P signaling via its cell surface receptor S1PR1 has been shown …

Background and Aims: KRP203 is a potent oral agonist of the sphingosine-1-phosphate
receptor subtype 1 that induces the sequestration of peripheral lymphocytes, thereby …

Pancreatic islet transplantation is a promising method for the treatment of type 1 and type 3
diabetes whereby replacement of islets may be curative. However, long-term treatment with …

The liver is an important organ in the regulation of glucose and lipid metabolism. It is
responsible for systemic energy homeostasis. When energy need exceeds the storage …

Liver fibrosis is an excess production of extracellular matrix proteins as a result of chronic
liver disease which leads to cell death and organ dysfunction. The key cells involved in …