[HTML][HTML] All models are wrong, but some are useful: Establishing standards for stem cell-based embryo models

E Posfai, F Lanner, C Mulas, HG Leitch - Stem Cell Reports, 2021 - cell.com
Detailed studies of the embryo allow an increasingly mechanistic understanding of
development, which has proved of profound relevance to human disease. The last decade …

The advantages and shortcomings of stem cell therapy for enhanced bone healing

SKH Chow, Q Gao, A Pius, M Morita… - … Engineering Part C …, 2024 - liebertpub.com
This review explores the regenerative potential of key progenitor cell types and therapeutic
strategies to improve healing of complex fractures and bone defects. We define, summarize …

Recognizing the differentiation degree of human induced pluripotent stem cell-derived retinal pigment epithelium cells using machine learning and deep learning …

CY Lien, TT Chen, ET Tsai, YJ Hsiao, N Lee, CE Gao… - Cells, 2023 - mdpi.com
Induced pluripotent stem cells (iPSCs) can be differentiated into mesenchymal stem cells
(iPSC-MSCs), retinal ganglion cells (iPSC-RGCs), and retinal pigmental epithelium cells …

Minimum criteria for defining induced mesenchymal stem cells

MS Choudhery, R Mahmood, DT Harris… - Cell biology …, 2022 - Wiley Online Library
Mesenchymal stem cells (MSCs) are a promising cell type for cell‐based therapies. The
therapeutic potential of MSCs has been verified in preclinical and clinical studies, however; …

Cloning in action: can embryo splitting, induced pluripotency and somatic cell nuclear transfer contribute to endangered species conservation?

A Swegen, R Appeltant, SA Williams - Biological Reviews, 2023 - Wiley Online Library
The term 'cloning'refers to the production of genetically identical individuals but has meant
different things throughout the history of science: a natural means of reproduction in …

Functionally-relevant morphological profiling: a tool to assess cellular heterogeneity

RA Marklein, J Lam, M Guvendiren, KE Sung… - Trends in …, 2018 - cell.com
Heterogeneity in cell function has presented a significant hurdle to the successful clinical
translation of many cellular therapies. Current techniques for assessing cell quality and the …

YTHDF2 destabilizes m6A-modified neural-specific RNAs to restrain differentiation in induced pluripotent stem cells

AM Heck, J Russo, J Wilusz, EO Nishimura, CJ Wilusz - Rna, 2020 - rnajournal.cshlp.org
N 6-methyladenosine (m6A) is an abundant post-transcriptional modification that can impact
RNA fate via interactions with m6A-specific RNA binding proteins. Despite accumulating …

The use of induced pluripotent stem cells in domestic animals: a narrative review

RA Scarfone, SM Pena, KA Russell, DH Betts… - BMC veterinary …, 2020 - Springer
Induced pluripotent stem cells (iPSCs) are undifferentiated stem cells characterized by the
ability to differentiate into any cell type in the body. iPSCs are a relatively new and rapidly …

Reproducible production and image-based quality evaluation of retinal pigment epithelium sheets from human induced pluripotent stem cells

K Ye, Y Takemoto, A Ito, M Onda, N Morimoto… - Scientific Reports, 2020 - nature.com
Transplantation of retinal pigment epithelial (RPE) sheets derived from human induced
pluripotent cells (hiPSC) is a promising cell therapy for RPE degeneration, such as in age …

[HTML][HTML] Current developments in the stable production of human induced pluripotent stem cells

I Horiguchi, M Kino-oka - Engineering, 2021 - Elsevier
Induced pluripotent stem cells (iPSCs) are considered to be ideal and promising cell
sources for various applications such as regenerative medicine and drug screening …