Germ cells may be defined as those cells, all of whose surviving descendants will become
sperm or eggs. In all sexually reproducing animals and plants, these cells play a uniquely …

Cell migration is a fundamental process that occurs during embryo development. Classic
studies using in vitro culture systems have been instrumental in dissecting the principles of …

Although spermatogenesis is essential for reproduction, little is known about spermatogonial
stem cells. These cells provide the basis for spermatogenesis throughout adult life by …

In Chance, Development, and Aging, two leading biological gerontologists review and
evaluate all of the available data to elucidate the respective roles played by genes and …

All metazoans that reproduce sexually have the ability to form gametes. Both types of
gametes, the egg and the sperm, arise from germ cells, undergo a unique program of …

Mouse primordial germ cells (PGCs) are specified between embryonic day 6.5 (E6. 5) and
E7. 5, when they have been visualized as an alkaline phosphatase-positive (AP+) cell …

In all animals information is passed from parent to offspring via the germline, which
segregates from the soma early in development and undergoes a complex developmental …

The germ cell lineage in the mouse becomes lineage-restricted about 7.2 days post coitum.
Its progenitors have migrated from the proximal region of the epiblast, where they were …

Primordial germ cells are the founder cells of the gametes. They are set aside at the initial
stages of gastrulation in mammals, become embedded in the hind-gut endoderm, then …

The family of interferon-induced transmembrane protein (Ifitm/mil/fragilis) genes encodes
cell surface proteins that may modulate cell adhesion and influence cell differentiation …