Does moderate drinking harm the fetal brain? Insights from animal models

CF Valenzuela, RA Morton, MR Diaz, L Topper - Trends in neurosciences, 2012 - cell.com
Although public health campaigns advise pregnant women to abstain from ethanol, drinking
during pregnancy is pervasive. Here, we highlight recent studies that have clearly …

[HTML][HTML] Focus on: neurotransmitter systems

CF Valenzuela, MP Puglia, S Zucca - Alcohol Research & Health, 2011 - ncbi.nlm.nih.gov
Neurotransmitter systems have been long recognized as important targets of the
developmental actions of alcohol (ie, ethanol). Short-and long-term effects of ethanol on …

Adenosine A2a receptors and O2 sensing in development

BJ Koos - … Journal of Physiology-Regulatory, Integrative and …, 2011 - journals.physiology.org
Reduced mitochondrial oxidative phosphorylation, via activation of adenylate kinase and the
resulting exponential rise in the cellular AMP/ATP ratio, appears to be a critical factor …

The serotonergic anatomy of the developing human medulla oblongata: implications for pediatric disorders of homeostasis

HC Kinney, KG Broadbelt, RL Haynes… - Journal of chemical …, 2011 - Elsevier
Abstract The caudal serotonergic (5-HT) system is a critical component of a medullary
“homeostatic network” that regulates protective responses to metabolic stressors such as …

Understanding and managing sleep disruption in children with fetal alcohol spectrum disorder

A Hanlon-Dearman, ML Chen… - Biochemistry and Cell …, 2018 - cdnsciencepub.com
Accumulating evidence has revealed high rates of sleep disruption among children with fetal
alcohol spectrum disorder (FASD). Multiple animal and clinical studies have found a clear …

Biomarkers of Affective Dysregulation Associated with In Utero Exposure to EtOH

N Darbinian, N Merabova, G Tatevosian, M Morrison… - Cells, 2023 - mdpi.com
Introduction: Children with fetal alcohol spectrum disorders (FASD) exhibit behavioral and
affective dysregulation, including hyperactivity and depression. The mechanisms are not …

Effects of prenatal and postnatal maternal ethanol on offspring response to alcohol and psychostimulants in long evans rats

E Barbier, H Houchi, V Warnault, O Pierrefiche… - Neuroscience, 2009 - Elsevier
An important factor that may influence addiction liability is exposure during the early life
period. Exposure to ethanol, early in life, can have long-lasting implications on brain function …

Caffeine reduces apnea frequency and enhances ventilatory long-term facilitation in rat pups raised in chronic intermittent hypoxia

CA Julien, V Joseph, A Bairam - Pediatric research, 2010 - nature.com
The mechanisms underlying the therapeutic function of caffeine on apneas in preterm
neonates are not well determined. To better understand these effects, we exposed rat pups …

Psilocybin-induced default mode network hypoconnectivity is blunted in alcohol-dependent rats

JR Reinwald, CN Schmitz, I Skorodumov… - Translational …, 2023 - nature.com
Abstract Alcohol Use Disorder (AUD) adversely affects the lives of millions of people, but still
lacks effective treatment options. Recent advancements in psychedelic research suggest …

GluN2B subunit of the NMDA receptor: the keystone of the effects of alcohol during neurodevelopment

M Naassila, O Pierrefiche - Neurochemical research, 2019 - Springer
The glutamatergic system plays a central role in both the acute and chronic effects of
ethanol. Among all the glutamate receptors the ionotropic NMDA receptors are crucial …